[(1S,2R)-3-[[(2,3-dihydro-2-oxo-1H-indol-5-yl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid (3R,3aS,6aR)-hexahydrofuro[2,3-b] furan-3-yl ester

Base Information

Chemical Name:[(1S,2R)-3-[[(2,3-dihydro-2-oxo-1H-indol-5-yl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid (3R,3aS,6aR)-hexahydrofuro[2,3-b] furan-3-yl ester
CAS No.:664344-17-6
Molecular Formula:C₂₉H₃₇N₃O₈S
Molecular Weight:587.694
Hs Code.:

[(1S,2R)-3-[[(2,3-dihydro-2-oxo-1H-indol-5-yl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid (3R,3aS,6aR)-hexahydrofuro[2,3-b] furan-3-yl ester

Synonyms:[(1S,2R)-3-[[(2,3-dihydro-2-oxo-1H-indol-5-yl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid (3R,3aS,6aR)-hexahydrofuro[2,3-b] furan-3-yl ester

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Chemical Property of [(1S,2R)-3-[[(2,3-dihydro-2-oxo-1H-indol-5-yl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid (3R,3aS,6aR)-hexahydrofuro[2,3-b] furan-3-yl ester

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Technology Process of [(1S,2R)-3-[[(2,3-dihydro-2-oxo-1H-indol-5-yl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid (3R,3aS,6aR)-hexahydrofuro[2,3-b] furan-3-yl ester

There total 8 articles about [(1S,2R)-3-[[(2,3-dihydro-2-oxo-1H-indol-5-yl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid (3R,3aS,6aR)-hexahydrofuro[2,3-b] furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 664344-42-7
[(1S,2R)-2-hydroxy-3-[(2-methylpropyl)amino]-1-(phenylmethyl)propyl]carbamic acid (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester

: 199328-31-9
2-oxo-2,3-dihydro-1H-indole-5-sulfonyl chloride

: 664344-17-6
[(1S,2R)-3-[[(2,3-dihydro-2-oxo-1H-indol-5-yl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid (3R,3aS,6aR)-hexahydrofuro[2,3-b] furan-3-yl ester

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield: 80.0%

: C₂₁H₃₂N₂O₅

: 664344-17-6
[(1S,2R)-3-[[(2,3-dihydro-2-oxo-1H-indol-5-yl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid (3R,3aS,6aR)-hexahydrofuro[2,3-b] furan-3-yl ester

Guidance literature:: With triethylamine; 2-oxo-2,3-dihydro-1H-indole-5-sulfonyl chloride; In dichloromethane; at 20 ℃; for 12h;

Reference yield:

: C₃₃H₄₄N₂O₃

: 664344-17-6
[(1S,2R)-3-[[(2,3-dihydro-2-oxo-1H-indol-5-yl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid (3R,3aS,6aR)-hexahydrofuro[2,3-b] furan-3-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium on activated carbon / methanol / 24 h / 20 °C

2: triethylamine / dichloromethane / 24 h / 20 °C

3: hydrogenchloride / ethanol; isopropyl alcohol / 24 h / 20 °C

4: triethylamine; 2-oxo-2,3-dihydro-1H-indole-5-sulfonyl chloride / dichloromethane / 12 h / 20 °C

With hydrogenchloride; hydrogen; triethylamine; 2-oxo-2,3-dihydro-1H-indole-5-sulfonyl chloride; palladium on activated carbon; In methanol; ethanol; dichloromethane; isopropyl alcohol;