(20-benzyl-5-isobutyl-8,13-diisopropyl-17,21-dimethyl-4,7,10,15,19,22-hexaoxo-12-triisopropylsilanyloxy-eicosahydro-9,18-dioxa-3a,6,14,21-tetraaza-cyclopentacycloheneicosen-16-yl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:(20-benzyl-5-isobutyl-8,13-diisopropyl-17,21-dimethyl-4,7,10,15,19,22-hexaoxo-12-triisopropylsilanyloxy-eicosahydro-9,18-dioxa-3a,6,14,21-tetraaza-cyclopentacycloheneicosen-16-yl)-carbamic acid tert-butyl ester
CAS No.:766513-73-9
Molecular Formula:C₅₁H₈₅N₅O₁₁Si
Molecular Weight:972.348
Hs Code.:

(20-benzyl-5-isobutyl-8,13-diisopropyl-17,21-dimethyl-4,7,10,15,19,22-hexaoxo-12-triisopropylsilanyloxy-eicosahydro-9,18-dioxa-3a,6,14,21-tetraaza-cyclopentacycloheneicosen-16-yl)-carbamic acid <i>tert</i>-butyl ester

Synonyms:(20-benzyl-5-isobutyl-8,13-diisopropyl-17,21-dimethyl-4,7,10,15,19,22-hexaoxo-12-triisopropylsilanyloxy-eicosahydro-9,18-dioxa-3a,6,14,21-tetraaza-cyclopentacycloheneicosen-16-yl)-carbamic acid tert-butyl ester

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Chemical Property of (20-benzyl-5-isobutyl-8,13-diisopropyl-17,21-dimethyl-4,7,10,15,19,22-hexaoxo-12-triisopropylsilanyloxy-eicosahydro-9,18-dioxa-3a,6,14,21-tetraaza-cyclopentacycloheneicosen-16-yl)-carbamic acid tert-butyl ester

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Technology Process of (20-benzyl-5-isobutyl-8,13-diisopropyl-17,21-dimethyl-4,7,10,15,19,22-hexaoxo-12-triisopropylsilanyloxy-eicosahydro-9,18-dioxa-3a,6,14,21-tetraaza-cyclopentacycloheneicosen-16-yl)-carbamic acid tert-butyl ester

There total 14 articles about (20-benzyl-5-isobutyl-8,13-diisopropyl-17,21-dimethyl-4,7,10,15,19,22-hexaoxo-12-triisopropylsilanyloxy-eicosahydro-9,18-dioxa-3a,6,14,21-tetraaza-cyclopentacycloheneicosen-16-yl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 876954-06-2
4-amino-5-methyl-3-triisopropylsilanyloxy-hexanoic acid 1-[1-(2-{[1-(2-tert-butoxycarbonylamino-2-carboxy-1-methyl-ethoxycarbonyl)-2-phenyl-ethyl]-methyl-carbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-butylcarbamoyl]-2-methyl-propyl ester

: 766513-73-9
(20-benzyl-5-isobutyl-8,13-diisopropyl-17,21-dimethyl-4,7,10,15,19,22-hexaoxo-12-triisopropylsilanyloxy-eicosahydro-9,18-dioxa-3a,6,14,21-tetraaza-cyclopentacycloheneicosen-16-yl)-carbamic acid tert-butyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1021/ol0530023

Reference yield:

: 766513-72-8
C₆₅H₁₀₇N₅O₁₅Si₂

: 766513-73-9
(20-benzyl-5-isobutyl-8,13-diisopropyl-17,21-dimethyl-4,7,10,15,19,22-hexaoxo-12-triisopropylsilanyloxy-eicosahydro-9,18-dioxa-3a,6,14,21-tetraaza-cyclopentacycloheneicosen-16-yl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 130 mg / MgBr₂*Et₂O / CH₂Cl₂ / 0 - 20 °C

2: 78 percent / hydrogen / Pd(OH)2 / methanol / 760.05 Torr

3: 10 mg / HATU; DIEA / dimethylformamide / 0 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; magnesium bromide; palladium dihydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo070412r

Reference yield:

: 766513-71-7
(2S,3R)-3-((S)-2-{[(S)-1-((S)-2-Amino-4-methyl-pentanoyl)-pyrrolidine-2-carbonyl]-methyl-amino}-3-phenyl-propionyloxy)-2-tert-butoxycarbonylamino-butyric acid 2-trimethylsilanyl-ethoxymethyl ester

: 766513-73-9
(20-benzyl-5-isobutyl-8,13-diisopropyl-17,21-dimethyl-4,7,10,15,19,22-hexaoxo-12-triisopropylsilanyloxy-eicosahydro-9,18-dioxa-3a,6,14,21-tetraaza-cyclopentacycloheneicosen-16-yl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 44 percent / DIEA; 4-(dimethylamino)pyridine / CH₂Cl₂ / 2 h / 0 - 20 °C

2: 130 mg / MgBr₂*Et₂O / CH₂Cl₂ / 0 - 20 °C

3: 78 percent / hydrogen / Pd(OH)2 / methanol / 760.05 Torr

4: 10 mg / HATU; DIEA / dimethylformamide / 0 °C

With dmap; hydrogen; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; magnesium bromide; palladium dihydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo070412r