[1-[6-(2-benzenesulfonyl-1,1-dimethyl-ethyl)-3,4-dihydro-2H-pyran-2-ylmethyl]-2-(4-methoxy-benzyloxy)-propoxy]-tert-butyl-dimethyl-silane

Base Information

Chemical Name:[1-[6-(2-benzenesulfonyl-1,1-dimethyl-ethyl)-3,4-dihydro-2H-pyran-2-ylmethyl]-2-(4-methoxy-benzyloxy)-propoxy]-tert-butyl-dimethyl-silane
CAS No.:215876-19-0
Molecular Formula:C₃₃H₅₀O₆SSi
Molecular Weight:602.908
Hs Code.:

[1-[6-(2-benzenesulfonyl-1,1-dimethyl-ethyl)-3,4-dihydro-2<i>H</i>-pyran-2-ylmethyl]-2-(4-methoxy-benzyloxy)-propoxy]-<i>tert</i>-butyl-dimethyl-silane

Synonyms:[1-[6-(2-benzenesulfonyl-1,1-dimethyl-ethyl)-3,4-dihydro-2H-pyran-2-ylmethyl]-2-(4-methoxy-benzyloxy)-propoxy]-tert-butyl-dimethyl-silane

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Chemical Property of [1-[6-(2-benzenesulfonyl-1,1-dimethyl-ethyl)-3,4-dihydro-2H-pyran-2-ylmethyl]-2-(4-methoxy-benzyloxy)-propoxy]-tert-butyl-dimethyl-silane

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Technology Process of [1-[6-(2-benzenesulfonyl-1,1-dimethyl-ethyl)-3,4-dihydro-2H-pyran-2-ylmethyl]-2-(4-methoxy-benzyloxy)-propoxy]-tert-butyl-dimethyl-silane

There total 16 articles about [1-[6-(2-benzenesulfonyl-1,1-dimethyl-ethyl)-3,4-dihydro-2H-pyran-2-ylmethyl]-2-(4-methoxy-benzyloxy)-propoxy]-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 215876-18-9
(7S,9R,10R)-1-Benzenesulfonyl-9-(tert-butyl-dimethyl-silanyloxy)-7-hydroxy-10-(4-methoxy-benzyloxy)-2,2-dimethyl-undecan-3-one

: 215876-19-0
[1-[6-(2-benzenesulfonyl-1,1-dimethyl-ethyl)-3,4-dihydro-2H-pyran-2-ylmethyl]-2-(4-methoxy-benzyloxy)-propoxy]-tert-butyl-dimethyl-silane

Guidance literature:: With camphor-10-sulfonic acid; In benzene; at 80 ℃;
DOI:10.1021/ja990860j

Reference yield:

: (R)-1-Benzenesulfonyl-7-hydroxy-10-(4-methoxy-benzyloxy)-2,2-dimethyl-undecane-3,9-dione

: 215876-19-0
[1-[6-(2-benzenesulfonyl-1,1-dimethyl-ethyl)-3,4-dihydro-2H-pyran-2-ylmethyl]-2-(4-methoxy-benzyloxy)-propoxy]-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / SmI₂ / tetrahydrofuran / 0 °C

2: 2,6-lutidine / CH₂Cl₂ / -15 °C

3: 88 percent / aq. LiOH / methanol; tetrahydrofuran

4: 96 percent / CSA / benzene / 80 °C

With 2,6-dimethylpyridine; lithium hydroxide; samarium diiodide; camphor-10-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane; benzene; 1: Tischenko reduction / 2: silylation / 3: Hydrolysis / 4: Dehydration;
DOI:10.1021/ja990860j

Reference yield:

: 215876-17-8
4-Nitro-benzoic acid (S)-7-benzenesulfonyl-1-[(2R,3R)-2-hydroxy-3-(4-methoxy-benzyloxy)-butyl]-6,6-dimethyl-5-oxo-heptyl ester

: 215876-19-0
[1-[6-(2-benzenesulfonyl-1,1-dimethyl-ethyl)-3,4-dihydro-2H-pyran-2-ylmethyl]-2-(4-methoxy-benzyloxy)-propoxy]-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1: 2,6-lutidine / CH₂Cl₂ / -15 °C

2: 88 percent / aq. LiOH / methanol; tetrahydrofuran

3: 96 percent / CSA / benzene / 80 °C

With 2,6-dimethylpyridine; lithium hydroxide; camphor-10-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane; benzene; 1: silylation / 2: Hydrolysis / 3: Dehydration;
DOI:10.1021/ja990860j