N-{2-cyclopropyl-2-[(E)-2,2,2-trifluoro-ethoxyimino]-ethyl}-5-(3,4-dichloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

Base Information

Chemical Name:N-{2-cyclopropyl-2-[(E)-2,2,2-trifluoro-ethoxyimino]-ethyl}-5-(3,4-dichloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide
CAS No.:1382465-35-1
Molecular Formula:C₂₁H₁₇Cl₂F₆N₃O₃
Molecular Weight:544.281
Hs Code.:

Synonyms:N-{2-cyclopropyl-2-[(E)-2,2,2-trifluoro-ethoxyimino]-ethyl}-5-(3,4-dichloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

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Chemical Property of N-{2-cyclopropyl-2-[(E)-2,2,2-trifluoro-ethoxyimino]-ethyl}-5-(3,4-dichloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

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Technology Process of N-{2-cyclopropyl-2-[(E)-2,2,2-trifluoro-ethoxyimino]-ethyl}-5-(3,4-dichloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

There total 5 articles about N-{2-cyclopropyl-2-[(E)-2,2,2-trifluoro-ethoxyimino]-ethyl}-5-(3,4-dichloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6226-25-1
2,2,2-trifluoroethyl trifluoromethanesulphonate

: 1382465-24-8
N-(E)-(2-cyclopropyl-2-hydroxyimino-ethyl)-5-(3,4-dichloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

: 1382465-67-9
N-{2-cyclopropyl-2-[(Z)-2,2,2-trifluoro-ethoxyimino]-ethyl}-5-(3,4-dichloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

: 1382465-35-1
N-{2-cyclopropyl-2-[(E)-2,2,2-trifluoro-ethoxyimino]-ethyl}-5-(3,4-dichloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

Guidance literature:: N-(E)-(2-cyclopropyl-2-hydroxyimino-ethyl)-5-(3,4-dichloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

2,2,2-trifluoroethyl trifluoromethanesulphonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

Reference yield:

: 1373754-96-1
5-(3,4-dichloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid

: 1382465-67-9
N-{2-cyclopropyl-2-[(Z)-2,2,2-trifluoro-ethoxyimino]-ethyl}-5-(3,4-dichloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

: 1382465-35-1
N-{2-cyclopropyl-2-[(E)-2,2,2-trifluoro-ethoxyimino]-ethyl}-5-(3,4-dichloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 20 °C

2.1: trifluoroacetic acid / 0.5 h / 20 °C

2.2: 0.5 h / 20 °C

3.1: hydroxylamine / water; methanol / 18 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

4.2: 0.5 h / 20 °C

With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; hydroxylamine; sodium hydride; trifluoroacetic acid; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 5-(3,4-dichlorophenyl)-6-(2,2,2-trifluoroethoxy)nicotinoyl chloride

: 1382465-67-9
N-{2-cyclopropyl-2-[(Z)-2,2,2-trifluoro-ethoxyimino]-ethyl}-5-(3,4-dichloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

: 1382465-35-1
N-{2-cyclopropyl-2-[(E)-2,2,2-trifluoro-ethoxyimino]-ethyl}-5-(3,4-dichloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / 0.5 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: hydroxylamine / water; methanol / 18 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 0.5 h / 20 °C

With hydroxylamine; sodium hydride; trifluoroacetic acid; In methanol; water; N,N-dimethyl-formamide;