3-Hydroxy-2-(4-hydroxy-3-methoxy-phenyl)-5,7,8-trimethoxy-6-methoxymethoxy-chromen-4-one

Base Information

Chemical Name:3-Hydroxy-2-(4-hydroxy-3-methoxy-phenyl)-5,7,8-trimethoxy-6-methoxymethoxy-chromen-4-one
CAS No.:173217-65-7
Molecular Formula:C₂₁H₂₂O₁₀
Molecular Weight:434.4
Hs Code.:

Synonyms:3-Hydroxy-2-(4-hydroxy-3-methoxy-phenyl)-5,7,8-trimethoxy-6-methoxymethoxy-chromen-4-one

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Chemical Property of 3-Hydroxy-2-(4-hydroxy-3-methoxy-phenyl)-5,7,8-trimethoxy-6-methoxymethoxy-chromen-4-one

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Technology Process of 3-Hydroxy-2-(4-hydroxy-3-methoxy-phenyl)-5,7,8-trimethoxy-6-methoxymethoxy-chromen-4-one

There total 8 articles about 3-Hydroxy-2-(4-hydroxy-3-methoxy-phenyl)-5,7,8-trimethoxy-6-methoxymethoxy-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 173217-77-1
2-(4-Benzyloxy-3-methoxy-phenyl)-3-hydroxy-5,7,8-trimethoxy-6-methoxymethoxy-chromen-4-one

: 173217-65-7
3-Hydroxy-2-(4-hydroxy-3-methoxy-phenyl)-5,7,8-trimethoxy-6-methoxymethoxy-chromen-4-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; ethyl acetate;
DOI:10.1248/cpb.43.2054

Reference yield:

: 1486-52-8
3-methoxy-4-benzyloxybenzoyl chloride

: 173217-65-7
3-Hydroxy-2-(4-hydroxy-3-methoxy-phenyl)-5,7,8-trimethoxy-6-methoxymethoxy-chromen-4-one

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / 2 h / 60 - 80 °C

2: KOH, pyridine / 2 h / 60 - 70 °C

3: H₂SO₄, AcOH / 1 h / 50 °C

4: 100 percent / N,N-diisopropylethylamine / CH₂Cl₂

5: 1.) dimethyldioxirane, 2.) TsOH / 1.) acetone, CH₂Cl₂, 0 deg C, 12 h, 2.) CH₂Cl₂, 0 deg C, 20 min

6: 96 percent / H₂ / 10percent Pd/C / methanol; ethyl acetate

With pyridine; potassium hydroxide; sulfuric acid; hydrogen; 3,3-dimethyldioxirane; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate;
DOI:10.1248/cpb.43.2054

Reference yield:

: 55742-65-9
2',5'-dihydroxy-3',4',6'-trimethoxyacetophenone

: 173217-65-7
3-Hydroxy-2-(4-hydroxy-3-methoxy-phenyl)-5,7,8-trimethoxy-6-methoxymethoxy-chromen-4-one

Guidance literature:: Multi-step reaction with 7 steps

1: N,N-diisopropylethylamine / CH₂Cl₂ / 4 h / Ambient temperature

2: pyridine / 2 h / 60 - 80 °C

3: KOH, pyridine / 2 h / 60 - 70 °C

4: H₂SO₄, AcOH / 1 h / 50 °C

5: 100 percent / N,N-diisopropylethylamine / CH₂Cl₂

6: 1.) dimethyldioxirane, 2.) TsOH / 1.) acetone, CH₂Cl₂, 0 deg C, 12 h, 2.) CH₂Cl₂, 0 deg C, 20 min

7: 96 percent / H₂ / 10percent Pd/C / methanol; ethyl acetate

With pyridine; potassium hydroxide; sulfuric acid; hydrogen; 3,3-dimethyldioxirane; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate;
DOI:10.1248/cpb.43.2054