(S)-N-[[3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl]amine p-tolueneaulfonate salt

Base Information

Chemical Name:(S)-N-[[3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl]amine p-tolueneaulfonate salt
CAS No.:1334229-25-2
Molecular Formula:C₇H₈O₃S*C₁₄H₁₈FN₃O₃
Molecular Weight:467.518
Hs Code.:

Synonyms:(S)-N-[[3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl]amine p-tolueneaulfonate salt

Suppliers and Price of (S)-N-[[3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl]amine p-tolueneaulfonate salt

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-[[3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl]amine p-tolueneaulfonate salt

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-N-[[3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl]amine p-tolueneaulfonate salt

There total 6 articles about (S)-N-[[3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl]amine p-tolueneaulfonate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 168828-83-9
(R)-[N-3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl 4-methylbenzenesulfonate

: 1334229-25-2
(S)-N-[[3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl]amine p-tolueneaulfonate salt

Guidance literature:: With ammonium hydroxide; In tetrahydrofuran; Isopropyl acetate; water; at 80 - 85 ℃; for 24h; Autoclave;

Reference yield:

: 2689-39-6
3-fluoro-4-(4-morpholinyl)nitrobenzene

: 1334229-25-2
(S)-N-[[3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl]amine p-tolueneaulfonate salt

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / nickel / ethanolamine; methanol / 20 °C / 3677.86 Torr

2.1: sodium carbonate / dichloromethane / 5 - 25 °C

3.1: n-butyllithium / hexane; tetrahydrofuran / 3.5 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C

3.3: 0.5 h / 20 °C

4.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C

5.1: ammonium hydroxide / isopropyl alcohol; water; tetrahydrofuran / 24 h / 80 - 85 °C / autoclave

With ammonium hydroxide; n-butyllithium; hydrogen; sodium carbonate; triethylamine; nickel; In tetrahydrofuran; methanol; hexane; dichloromethane; water; ethanolamine; isopropyl alcohol;

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 1334229-25-2
(S)-N-[[3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl]amine p-tolueneaulfonate salt

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / water / 18 h / 20 - 85 °C

2.1: hydrogen / nickel / ethanolamine; methanol / 20 °C / 3677.86 Torr

3.1: sodium carbonate / dichloromethane / 5 - 25 °C

4.1: n-butyllithium / hexane; tetrahydrofuran / 3.5 h / -78 °C / Inert atmosphere

4.2: -78 - 20 °C

4.3: 0.5 h / 20 °C

5.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C

6.1: ammonium hydroxide / isopropyl alcohol; water; tetrahydrofuran / 24 h / 80 - 85 °C / autoclave

With ammonium hydroxide; n-butyllithium; hydrogen; sodium carbonate; triethylamine; nickel; In tetrahydrofuran; methanol; hexane; dichloromethane; water; ethanolamine; isopropyl alcohol;