methyl 3-(6-amino-4-(ethoxycarbonyl)-5-methylpyrimidin-2-yl)-3(R)-aminopropionate

Base Information

Chemical Name:methyl 3-(6-amino-4-(ethoxycarbonyl)-5-methylpyrimidin-2-yl)-3(R)-aminopropionate
CAS No.:157916-84-2
Molecular Formula:C₁₂H₁₈N₄O₄
Molecular Weight:282.299
Hs Code.:

Synonyms:methyl 3-(6-amino-4-(ethoxycarbonyl)-5-methylpyrimidin-2-yl)-3(R)-aminopropionate

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Chemical Property of methyl 3-(6-amino-4-(ethoxycarbonyl)-5-methylpyrimidin-2-yl)-3(R)-aminopropionate

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Technology Process of methyl 3-(6-amino-4-(ethoxycarbonyl)-5-methylpyrimidin-2-yl)-3(R)-aminopropionate

There total 1 articles about methyl 3-(6-amino-4-(ethoxycarbonyl)-5-methylpyrimidin-2-yl)-3(R)-aminopropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 898-22-6
triethyl 1,3,5-triazine-2,4,6-tricarboxylate

: 157916-84-2
methyl 3-(6-amino-4-(ethoxycarbonyl)-5-methylpyrimidin-2-yl)-3(R)-aminopropionate

Guidance literature:: Multi-step reaction with 9 steps

1: 95 percent / dioxane / 21 h / 101 °C

2: 75 percent / CF₃SO₃H / CH₂Cl₂ / 13 h / 40 °C

3: NaBH₄ / ethanol / 15 h / 25 °C

4: 83 percent / MnO₂ / acetonitrile / 3 h / 82 °C

5: 1.) Bu₂BOTf, i-Pr₂NEt, / 1.) CH₂Cl₂, 0 deg C, 1 h, 2.) CH₂Cl₂, 0 deg C, 3 h

6: 93 percent / Bu₃SnH, AIBN / benzene / 1 h / 80 °C

7: 52 percent / DEAD, hydrazoic acid, Ph₃P / tetrahydrofuran / 16 h / 23 °C

8: 59 percent / NaOCH₃ / 0.33 h / 0 °C

9: 82 percent / Ph₃P, H₂O, HOAc / tetrahydrofuran / 15 h / 25 °C

With manganese(IV) oxide; sodium tetrahydroborate; hydrogen azide; 2,2'-azobis(isobutyronitrile); trifluorormethanesulfonic acid; di-n-butylboryl trifluoromethanesulfonate; water; tri-n-butyl-tin hydride; sodium methylate; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; acetonitrile; benzene;
DOI:10.1021/ja00092a012