Technology Process of C17H18FNO2*ClH
There total 10 articles about C17H18FNO2*ClH which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride; water;
In
ethyl acetate;
at 20 ℃;
for 1h;
Inert atmosphere;
DOI:10.1021/jm2007062
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: caesium carbonate / methanol; water / pH 8 / Inert atmosphere
1.2: 1 h / 20 °C / Inert atmosphere
2.1: hydrogenchloride; water / ethyl acetate / 1 h / 20 °C / Inert atmosphere
With
hydrogenchloride; water; caesium carbonate;
In
methanol; water; ethyl acetate;
DOI:10.1021/jm2007062
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: copper(I) bromide dimethylsulfide complex; methylmagnesium bromide / tetrahydrofuran; dimethylsulfide; dibutyl ether / 0 - 20 °C / Inert atmosphere
2.1: di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / -78 °C / Inert atmosphere
2.2: 3 h / -78 - 0 °C / Inert atmosphere
3.1: sodium azide / dimethyl sulfoxide / 45 h / 20 °C / Inert atmosphere
4.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / Inert atmosphere
5.1: lithium hydroxide / tetrahydrofuran; water / 1 h / 0 °C / Inert atmosphere
6.1: caesium carbonate / methanol; water / pH 8 / Inert atmosphere
6.2: 1 h / 20 °C / Inert atmosphere
7.1: hydrogenchloride; water / ethyl acetate / 1 h / 20 °C / Inert atmosphere
With
hydrogenchloride; sodium azide; copper(I) bromide dimethylsulfide complex; di-n-butylboryl trifluoromethanesulfonate; palladium 10% on activated carbon; methylmagnesium bromide; water; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; lithium hydroxide;
In
tetrahydrofuran; methanol; dimethylsulfide; dichloromethane; dibutyl ether; water; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/jm2007062
