N-((1R,2S)-1-hydroxy-1-phenylpropan-2-yl)-2-iodo-5-methoxy-3-methylbenzamide

Base Information

Chemical Name:N-((1R,2S)-1-hydroxy-1-phenylpropan-2-yl)-2-iodo-5-methoxy-3-methylbenzamide
CAS No.:1415764-23-6
Molecular Formula:C₁₈H₂₀INO₃
Molecular Weight:425.266
Hs Code.:

Synonyms:N-((1R,2S)-1-hydroxy-1-phenylpropan-2-yl)-2-iodo-5-methoxy-3-methylbenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((1R,2S)-1-hydroxy-1-phenylpropan-2-yl)-2-iodo-5-methoxy-3-methylbenzamide

Chemical Property:

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Technology Process of N-((1R,2S)-1-hydroxy-1-phenylpropan-2-yl)-2-iodo-5-methoxy-3-methylbenzamide

There total 3 articles about N-((1R,2S)-1-hydroxy-1-phenylpropan-2-yl)-2-iodo-5-methoxy-3-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 492-41-1,58550-13-3,757124-50-8
(1R,2S)-norephedrine

: C₉H₈ClIO₂

: 1415764-23-6
N-((1R,2S)-1-hydroxy-1-phenylpropan-2-yl)-2-iodo-5-methoxy-3-methylbenzamide

Guidance literature:: With triethylamine; In 1,4-dioxane; at 0 - 20 ℃; for 18h; Inert atmosphere;
DOI:10.1021/jo302393u

Reference yield:

: 1415764-22-5
(2-iodo-5-methoxy-3-methylphenyl)methanol

: 1415764-23-6
N-((1R,2S)-1-hydroxy-1-phenylpropan-2-yl)-2-iodo-5-methoxy-3-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: Jones reagent / acetone / 18.33 h / 0 - 20 °C

1.2: 1 h / 0 - 20 °C

2.1: thionyl chloride; N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere

3.1: triethylamine / 1,4-dioxane / 18 h / 0 - 20 °C / Inert atmosphere

With Jones reagent; thionyl chloride; triethylamine; N,N-dimethyl-formamide; In 1,4-dioxane; acetone;
DOI:10.1021/jo302393u

Reference yield:

: 1005786-30-0
2-iodo-3-methyl-5-methoxybenzoic acid

: 1415764-23-6
N-((1R,2S)-1-hydroxy-1-phenylpropan-2-yl)-2-iodo-5-methoxy-3-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride; N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere

2: triethylamine / 1,4-dioxane / 18 h / 0 - 20 °C / Inert atmosphere

With thionyl chloride; triethylamine; N,N-dimethyl-formamide; In 1,4-dioxane;
DOI:10.1021/jo302393u