N'-[1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrazolo[3,4-d]pyrimidin-4-yl]-N,N-dimethylmethanimidamide

Base Information

Chemical Name:N'-[1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrazolo[3,4-d]pyrimidin-4-yl]-N,N-dimethylmethanimidamide
CAS No.:78586-44-4
Molecular Formula:C₁₃H₁₈N₆O₄
Molecular Weight:322.324
Hs Code.:
DSSTox Substance ID:DTXSID00421130

Synonyms:NSC270539;DTXSID00421130;78586-44-4

Suppliers and Price of N'-[1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrazolo[3,4-d]pyrimidin-4-yl]-N,N-dimethylmethanimidamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of N'-[1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrazolo[3,4-d]pyrimidin-4-yl]-N,N-dimethylmethanimidamide

Chemical Property:

Vapor Pressure:1.2E-15mmHg at 25°C
Boiling Point:608.2°Cat760mmHg
Flash Point:321.6°C
Density:1.66g/cm³
XLogP3:-1.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:322.13895308
Heavy Atom Count:23
Complexity:439

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C)C=NC1=C2C=NN(C2=NC=N1)C3C(C(C(O3)CO)O)O
Isomeric SMILES:CN(C)/C=N/C1=C2C=NN(C2=NC=N1)C3C(C(C(O3)CO)O)O

Technology Process of N'-[1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrazolo[3,4-d]pyrimidin-4-yl]-N,N-dimethylmethanimidamide

There total 3 articles about N'-[1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrazolo[3,4-d]pyrimidin-4-yl]-N,N-dimethylmethanimidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 3258-05-7
4-amino-1-(β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine

: 78586-44-4
4-<<(dimethylamino)methylene>amino>-1-(β-D-ribofuranosyl)pyrazolo<3,4-d>pyrimidine

Guidance literature:: In N,N-dimethyl-formamide; for 48h; Ambient temperature;
DOI:10.1021/jm00142a009

Reference yield:

: 64372-69-6
1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)pyrazolo<3,4-d>pyrimidin-4-one

: 78586-44-4
4-<<(dimethylamino)methylene>amino>-1-(β-D-ribofuranosyl)pyrazolo<3,4-d>pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / thionyl chloride, DMF / CH₂Cl₂ / 14 h / 60 °C

2: 90 percent / 28percent ammonium hydroxide / 2 h / Heating

3: 80 percent / dimethylformamide / 48 h / Ambient temperature

With ammonium hydroxide; thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00142a009

Reference yield:

: 78586-33-1
4-chloro-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)pyrazolo<3,4-d>pyrimidine

: 78586-44-4
4-<<(dimethylamino)methylene>amino>-1-(β-D-ribofuranosyl)pyrazolo<3,4-d>pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / 28percent ammonium hydroxide / 2 h / Heating

2: 80 percent / dimethylformamide / 48 h / Ambient temperature

With ammonium hydroxide; In N,N-dimethyl-formamide;
DOI:10.1021/jm00142a009