1-(4-chlorophenyl)-3-(4-(6-((3-(trifluoromethyl)phenyl)amino)pyrimidin-4-yl)phenyl)thiourea

Base Information

Chemical Name:1-(4-chlorophenyl)-3-(4-(6-((3-(trifluoromethyl)phenyl)amino)pyrimidin-4-yl)phenyl)thiourea
CAS No.:1376770-28-3
Molecular Formula:C₂₄H₁₇ClF₃N₅S
Molecular Weight:499.947
Hs Code.:

Synonyms:1-(4-chlorophenyl)-3-(4-(6-((3-(trifluoromethyl)phenyl)amino)pyrimidin-4-yl)phenyl)thiourea

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Chemical Property of 1-(4-chlorophenyl)-3-(4-(6-((3-(trifluoromethyl)phenyl)amino)pyrimidin-4-yl)phenyl)thiourea

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Technology Process of 1-(4-chlorophenyl)-3-(4-(6-((3-(trifluoromethyl)phenyl)amino)pyrimidin-4-yl)phenyl)thiourea

There total 6 articles about 1-(4-chlorophenyl)-3-(4-(6-((3-(trifluoromethyl)phenyl)amino)pyrimidin-4-yl)phenyl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1376770-17-0
6-(4-aminophenyl)-N-(3-(trifluoromethyl)phenyl)pyrimidin-4-amine

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 1376770-28-3
1-(4-chlorophenyl)-3-(4-(6-((3-(trifluoromethyl)phenyl)amino)pyrimidin-4-yl)phenyl)thiourea

Guidance literature:: In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmcl.2012.03.092

Reference yield:

: 954221-91-1
4-chloro-6-(4-nitrophenyl)pyrimidine

: 1376770-28-3
1-(4-chlorophenyl)-3-(4-(6-((3-(trifluoromethyl)phenyl)amino)pyrimidin-4-yl)phenyl)thiourea

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / water; isopropyl alcohol / 0.33 h / 100 °C / Microwave irradiation

2: tin(ll) chloride / ethyl acetate / 12 h / 20 °C

3: tetrahydrofuran / 20 °C

With hydrogenchloride; tin(ll) chloride; In tetrahydrofuran; water; ethyl acetate; isopropyl alcohol;
DOI:10.1016/j.bmcl.2012.03.092

Reference yield:

: 586-78-7
para-nitrophenyl bromide

: 1376770-28-3
1-(4-chlorophenyl)-3-(4-(6-((3-(trifluoromethyl)phenyl)amino)pyrimidin-4-yl)phenyl)thiourea

Guidance literature:: Multi-step reaction with 5 steps

1: potassium acetate; palladium diacetate / N,N-dimethyl-formamide / 2 h / 80 °C

2: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; ethanol; water / 0.33 h / 120 °C / Microwave irradiation

3: hydrogenchloride / water; isopropyl alcohol / 0.33 h / 100 °C / Microwave irradiation

4: tin(ll) chloride / ethyl acetate / 12 h / 20 °C

5: tetrahydrofuran / 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; potassium acetate; palladium diacetate; sodium carbonate; tin(ll) chloride; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2012.03.092