8-(4-fluorobenzyl)oxy-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]coumarin

Base Information

Chemical Name:8-(4-fluorobenzyl)oxy-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]coumarin
CAS No.:1260743-79-0
Molecular Formula:C₂₅H₁₇FN₂O₄
Molecular Weight:428.419
Hs Code.:

Synonyms:8-(4-fluorobenzyl)oxy-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]coumarin

Suppliers and Price of 8-(4-fluorobenzyl)oxy-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]coumarin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 8-(4-fluorobenzyl)oxy-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]coumarin

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 8-(4-fluorobenzyl)oxy-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]coumarin

There total 2 articles about 8-(4-fluorobenzyl)oxy-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]coumarin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 931717-78-1
8-hydroxy-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]coumarin

: 352-11-4
1-chloromethyl-4-fluorobenzene

: 1260743-79-0
8-(4-fluorobenzyl)oxy-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]coumarin

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 3h;
DOI:10.1002/jhet.893

Reference yield:

: 19227-13-5
p-toluamidoxime

: 1260743-79-0
8-(4-fluorobenzyl)oxy-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]coumarin

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,4-dioxane / 6 h / Reflux

2.1: piperidine / N,N-dimethyl-formamide / 0.33 h / 50 - 80 °C

2.2: 0.5 h / 100 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 70 °C

With piperidine; potassium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide; 2.1: |Knoevenagel Condensation;
DOI:10.1002/jhet.893