tert-butyl [4-(3-{[5-(2-tert-butoxycarbonylaminoethoxy)benzothiazol-2-ylmethyl]amino}[1,2,4]triazin-5-yl)-3,5-dimethylphenyl]carbamate

Base Information

Chemical Name:tert-butyl [4-(3-{[5-(2-tert-butoxycarbonylaminoethoxy)benzothiazol-2-ylmethyl]amino}[1,2,4]triazin-5-yl)-3,5-dimethylphenyl]carbamate
CAS No.:1203605-55-3
Molecular Formula:C₃₁H₃₉N₇O₅S
Molecular Weight:621.761
Hs Code.:

Synonyms:tert-butyl [4-(3-{[5-(2-tert-butoxycarbonylaminoethoxy)benzothiazol-2-ylmethyl]amino}[1,2,4]triazin-5-yl)-3,5-dimethylphenyl]carbamate

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Chemical Property of tert-butyl [4-(3-{[5-(2-tert-butoxycarbonylaminoethoxy)benzothiazol-2-ylmethyl]amino}[1,2,4]triazin-5-yl)-3,5-dimethylphenyl]carbamate

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Technology Process of tert-butyl [4-(3-{[5-(2-tert-butoxycarbonylaminoethoxy)benzothiazol-2-ylmethyl]amino}[1,2,4]triazin-5-yl)-3,5-dimethylphenyl]carbamate

There total 2 articles about tert-butyl [4-(3-{[5-(2-tert-butoxycarbonylaminoethoxy)benzothiazol-2-ylmethyl]amino}[1,2,4]triazin-5-yl)-3,5-dimethylphenyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1203605-54-2
[2-(2-aminomethylbenzothiazol-5-yloxy)ethyl]carbamic acid tert-butyl ester

: 1203605-36-0
[4-(3-chloro-[1,2,4]triazin-5-yl)-3,5-dimethylphenyl]carbamic acid tert-butyl ester

: 1203605-55-3
tert-butyl [4-(3-{[5-(2-tert-butoxycarbonylaminoethoxy)benzothiazol-2-ylmethyl]amino}[1,2,4]triazin-5-yl)-3,5-dimethylphenyl]carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 85 ℃; Inert atmosphere;

Reference yield: 58.0%

: 1203605-54-2
[2-(2-aminomethylbenzothiazol-5-yloxy)ethyl]carbamic acid tert-butyl ester

: C₁₅H₂₀ClN₅

: 1203605-55-3
tert-butyl [4-(3-{[5-(2-tert-butoxycarbonylaminoethoxy)benzothiazol-2-ylmethyl]amino}[1,2,4]triazin-5-yl)-3,5-dimethylphenyl]carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 85 ℃; Inert atmosphere;
DOI:10.1021/jm400097h

Reference yield: 73.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1203605-55-3
tert-butyl [4-(3-{[5-(2-tert-butoxycarbonylaminoethoxy)benzothiazol-2-ylmethyl]amino}[1,2,4]triazin-5-yl)-3,5-dimethylphenyl]carbamate

: 1203605-56-4
tert-butyl [2-(2-{[5-(4-amino-2,6-dimethyl-phenyl)-[1,2,4]triazin-3-ylamino]-methyl}-benzothiazol-5-yloxy)-ethyl]-carbamate

Guidance literature:: tert-butyl [4-(3-{[5-(2-tert-butoxycarbonylaminoethoxy)benzothiazol-2-ylmethyl]amino}[1,2,4]triazin-5-yl)-3,5-dimethylphenyl]carbamate; With hydrogenchloride; water; In ethyl acetate; at 0 - 20 ℃; for 1h;

With potassium hydroxide; In water; ethyl acetate;

di-tert-butyl dicarbonate; With triethylamine; In tetrahydrofuran; at 20 ℃;