6,6-dimethyl-3-perfluoropropyl-1-(4-fluorophenyl)-6,7-dihydro-1H-indazol-4(5H)-one

Base Information

• Chemical Name: 6,6-dimethyl-3-perfluoropropyl-1-(4-fluorophenyl)-6,7-dihydro-1H-indazol-4(5H)-one
• CAS No.: 1161924-88-4
• Molecular Formula: C₁₈H₁₄F₈N₂O
• Molecular Weight: 426.309

Synonyms:6,6-dimethyl-3-perfluoropropyl-1-(4-fluorophenyl)-6,7-dihydro-1H-indazol-4(5H)-one

Chemical Property of 6,6-dimethyl-3-perfluoropropyl-1-(4-fluorophenyl)-6,7-dihydro-1H-indazol-4(5H)-one

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Technology Process of 6,6-dimethyl-3-perfluoropropyl-1-(4-fluorophenyl)-6,7-dihydro-1H-indazol-4(5H)-one

There total 1 articles about 6,6-dimethyl-3-perfluoropropyl-1-(4-fluorophenyl)-6,7-dihydro-1H-indazol-4(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2-heptafluorobutyryl-5,5-dimethylcyclohexane-1,3-dione (950908-46-0) + 4-fluorophenyhydrazine hydrochloride (823-85-8) → 6,6-dimethyl-3-perfluoropropyl-1-(4-fluorophenyl)-6,7-dihydro-1H-indazol-4(5H)-one (1161924-88-4)

Guidance literature:

With sodium hydroxide; In ethanol; at 20 ℃; for 8h;

DOI:10.1134/S1070363208100241

Reference yield: 93.0%

6,6-dimethyl-3-perfluoropropyl-1-(4-fluorophenyl)-6,7-dihydro-1H-indazol-4(5H)-one (1161924-88-4) → (E)-6,6-dimethyl-3-perfluoropropyl-1-(4-fluorophenyl)-6,7-dihydro-1H-indazol-4(5H)-one oxime

Guidance literature:

With pyridine; hydroxylamine hydrochloride; for 3h; diastereoselective reaction; Reflux;

DOI:10.1134/S1070428015050115

Reference yield: 81.0%

6,6-dimethyl-3-perfluoropropyl-1-(4-fluorophenyl)-6,7-dihydro-1H-indazol-4(5H)-one (1161924-88-4) → 7-bromo-1-(4-fluorophenyl)-6,6-dimethyl-3-perfluoropropyl-6,7-dihydro-1H-indazol-4(5H)-one (1373316-14-3)

Guidance literature:

With N-Bromosuccinimide; In tetrachloromethane; for 8h; Reflux;

DOI:10.1134/S1070428012030128

upstream raw materials:

2-heptafluorobutyryl-5,5-dimethylcyclohexane-1,3-dione

4-fluorophenyhydrazine hydrochloride

Downstream raw materials:

7-bromo-1-(4-fluorophenyl)-6,6-dimethyl-3-perfluoropropyl-6,7-dihydro-1H-indazol-4(5H)-one

7-azido-1-(4-fluorophenyl)-6,6-dimethyl-3-perfluoropropyl-6,7-dihydro-1H-indazol-4(5H)-one

1-(4-fluorophenyl)-6,6-dimethyl-3-perfluoropropyl-7-(4-phenyl-1H-1,2,3-triazol-1-yl)-6,7-dihydro-1H-indazol-4(5H)-one

3-(4-fluorophenyl)-5,5-dimethyl-1-perfluoropropyl-4,5-dihydro-3H-pyrazolo[4,3-a]phenazine

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