Methyl 1,5-diphenyl-1H-imidazole-4-carboxylate

Base Information

Chemical Name:Methyl 1,5-diphenyl-1H-imidazole-4-carboxylate
CAS No.:130740-25-9
Molecular Formula:C₁₇H₁₄N₂O₂
Molecular Weight:278.31
Hs Code.:
DSSTox Substance ID:DTXSID701247232
Nikkaji Number:J341.373J

Synonyms:DTXSID701247232;130740-25-9;Methyl 1,5-diphenyl-1H-imidazole-4-carboxylate

Suppliers and Price of Methyl 1,5-diphenyl-1H-imidazole-4-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 1,5-diphenyl-1H-imidazole-4-carboxylate

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:278.105527694
Heavy Atom Count:21
Complexity:349

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C1=C(N(C=N1)C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of Methyl 1,5-diphenyl-1H-imidazole-4-carboxylate

There total 2 articles about Methyl 1,5-diphenyl-1H-imidazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 119826-05-0
(Z)-Methyl 3-bromo-2-isocyano-3-phenylacrylate

: 62-53-3
aniline

: 130740-25-9
Methyl 1,5-diphenylimidazole-4-carboxylate

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 25 ℃; for 48h;
DOI:10.1021/jo00104a018

Reference yield:

: 1265278-17-8
(Z)-methyl β-bromo-α-formylaminocinnamate

: 130740-25-9
Methyl 1,5-diphenylimidazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / POCl₃, Et₃N / CH₂Cl₂ / 2 h / 0 °C

2: 52 percent / Et₃N / dimethylformamide / 48 h / 25 °C

With triethylamine; trichlorophosphate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00104a018