2-amino-4-[2,4-dichloro-6-(2-(pyridin-2-yl)ethoxy)phenyl]-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclobutylamide

Base Information

Chemical Name:2-amino-4-[2,4-dichloro-6-(2-(pyridin-2-yl)ethoxy)phenyl]-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclobutylamide
CAS No.:1046859-41-9
Molecular Formula:C₂₄H₂₄Cl₂N₆O₂
Molecular Weight:499.4
Hs Code.:

Synonyms:2-amino-4-[2,4-dichloro-6-(2-(pyridin-2-yl)ethoxy)phenyl]-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclobutylamide

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Chemical Property of 2-amino-4-[2,4-dichloro-6-(2-(pyridin-2-yl)ethoxy)phenyl]-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclobutylamide

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Technology Process of 2-amino-4-[2,4-dichloro-6-(2-(pyridin-2-yl)ethoxy)phenyl]-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclobutylamide

There total 12 articles about 2-amino-4-[2,4-dichloro-6-(2-(pyridin-2-yl)ethoxy)phenyl]-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclobutylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 103-74-2
2-(2-Hydroxyethyl)pyridine

: 1046861-27-1
2-amino-4-(2,4-dichloro-6-hydroxyphenyl)-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclobutylamide

: 1046859-41-9
2-amino-4-[2,4-dichloro-6-(2-(pyridin-2-yl)ethoxy)phenyl]-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclobutylamide

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield:

: 1028332-19-5
3,5-dichloro-2-iodophenol

: 1046859-41-9
2-amino-4-[2,4-dichloro-6-(2-(pyridin-2-yl)ethoxy)phenyl]-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclobutylamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

2.1: palladium diacetate; triethylamine; CyJohnPhos / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

3.1: boron tribromide / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

3.2: Cooling

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane / 8 h / 85 °C / Inert atmosphere

5.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 23 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; di-isopropyl azodicarboxylate; palladium diacetate; boron tribromide; sodium carbonate; potassium carbonate; triethylamine; triphenylphosphine; CyJohnPhos; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; 4.1: Suzuki coupling;
DOI:10.1021/jm200128m

Reference yield:

: 1028332-20-8
1,5-dichloro-3-(ethoxymethoxy)-2-iodobenzene

: 1046859-41-9
2-amino-4-[2,4-dichloro-6-(2-(pyridin-2-yl)ethoxy)phenyl]-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclobutylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium diacetate; triethylamine; CyJohnPhos / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

2.1: boron tribromide / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

2.2: Cooling

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane / 8 h / 85 °C / Inert atmosphere

4.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 23 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; di-isopropyl azodicarboxylate; palladium diacetate; boron tribromide; sodium carbonate; triethylamine; triphenylphosphine; CyJohnPhos; In tetrahydrofuran; 1,4-dioxane; dichloromethane; 3.1: Suzuki coupling;
DOI:10.1021/jm200128m