6-bromo-3-(chloromethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one

Base Information

Chemical Name:6-bromo-3-(chloromethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one
CAS No.:447423-15-6
Molecular Formula:C₂₀H₁₉BrClNO
Molecular Weight:404.734
Hs Code.:

Synonyms:6-bromo-3-(chloromethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one

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Chemical Property of 6-bromo-3-(chloromethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one

Chemical Property:

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Technology Process of 6-bromo-3-(chloromethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one

There total 9 articles about 6-bromo-3-(chloromethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 447423-14-5
6-bromo-3-(hydroxymethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one

: 447423-15-6
6-bromo-3-(chloromethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one

Guidance literature:: With pyridine; thionyl chloride; In tetrahydrofuran; toluene;

Reference yield:

: 1332697-10-5
6-bromo-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid

: 447423-15-6
6-bromo-3-(chloromethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 2 h / 20 °C

2: sodium tetrahydroborate / tetrahydrofuran; 1,2-dimethoxyethane / 2 h / 0 °C

3: pyridine; thionyl chloride / tetrahydrofuran; toluene / 3 h / 20 °C

With pyridine; sodium tetrahydroborate; thionyl chloride; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; 1,2-dimethoxyethane; toluene;
DOI:10.1016/j.bmc.2011.06.059

Reference yield:

: C₂₁H₁₉BrO₇

: 447423-15-6
6-bromo-3-(chloromethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride; water; acetic acid / 8 h / 120 °C

2: methanol / 15 h / 20 °C

3: hydrogenchloride / ethyl acetate / 3 h / 20 °C

4: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 2 h / 20 °C

5: sodium tetrahydroborate / tetrahydrofuran; 1,2-dimethoxyethane / 2 h / 0 °C

6: pyridine; thionyl chloride / tetrahydrofuran; toluene / 3 h / 20 °C

With pyridine; hydrogenchloride; sodium tetrahydroborate; thionyl chloride; oxalyl dichloride; water; acetic acid; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethyl acetate; toluene;
DOI:10.1016/j.bmc.2011.06.059