C₂₄H₂₅F₃N₆O

Base Information

Chemical Name:C₂₄H₂₅F₃N₆O
CAS No.:1418731-93-7
Molecular Formula:C₂₄H₂₅F₃N₆O
Molecular Weight:470.497
Hs Code.:

C<sub>24</sub>H<sub>25</sub>F<sub>3</sub>N<sub>6</sub>O

Synonyms:C₂₄H₂₅F₃N₆O

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Chemical Property of C₂₄H₂₅F₃N₆O

Chemical Property:

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Technology Process of C₂₄H₂₅F₃N₆O

There total 13 articles about C₂₄H₂₅F₃N₆O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1393901-00-2
tert-butyl 4-(4-((4-(3-carbamoylphenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperazine-1-carboxylate

: 1418731-93-7
C₂₄H₂₅F₃N₆O

Guidance literature:: tert-butyl 4-(4-((4-(3-carbamoylphenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperazine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere;

With sodium hydroxide; In water; ethyl acetate;

Reference yield:

: 182618-86-6
tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate

: 1418731-93-7
C₂₄H₂₅F₃N₆O

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 42 h / 20 °C / Inert atmosphere

2.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 0.83 h / 0 °C

2.2: 18 h / 0 - 20 °C

3.1: triethylamine / triphenylphosphine; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride / N,N-dimethyl-formamide / 0.33 h / 120 °C / microwave irradiation

4.1: hydrogen / palladium 10% on activated carbon; 10 wt% Pd(OH)2 on carbon / ethyl acetate; N,N-dimethyl-formamide / 38 h / 20 °C / Inert atmosphere

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 17 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; ammonium carbonate / N,N-dimethyl-formamide; tetrahydrofuran / 60 h / 20 °C / Inert atmosphere

7.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C / Inert atmosphere

With lithium hydroxide monohydrate; water; hydrogen; ammonium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; zinc(II) chloride; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; palladium 10% on activated carbon; 10 wt% Pd(OH)2 on carbon; triphenylphosphine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 618-51-9
3-Iodobenzoic acid

: 1418731-93-7
C₂₄H₂₅F₃N₆O

Guidance literature:: Multi-step reaction with 9 steps

1.1: dmap / dichloromethane / 64 h / 20 °C / Inert atmosphere

2.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / tetrahydrofuran / 0.17 h / Inert atmosphere

2.2: 18 h

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 17 h / 0 - 20 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

4.2: 20 h / 65 °C

5.1: triethylamine / triphenylphosphine; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride / N,N-dimethyl-formamide / 0.33 h / 120 °C / microwave irradiation

6.1: hydrogen / palladium 10% on activated carbon; 10 wt% Pd(OH)2 on carbon / ethyl acetate; N,N-dimethyl-formamide / 38 h / 20 °C / Inert atmosphere

7.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 17 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; ammonium carbonate / N,N-dimethyl-formamide; tetrahydrofuran / 60 h / 20 °C / Inert atmosphere

9.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C / Inert atmosphere

With dmap; lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; water; hydrogen; ammonium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trans-bis(triphenylphosphine)palladium dichloride; palladium 10% on activated carbon; 10 wt% Pd(OH)2 on carbon; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;