N-((3E)-1-(benzyloxy)-5,5,5-trifluoropent-3-en-2-yl)-2,2,2-trichloroacetamide

Base Information

Chemical Name:N-((3E)-1-(benzyloxy)-5,5,5-trifluoropent-3-en-2-yl)-2,2,2-trichloroacetamide
CAS No.:1415354-90-3
Molecular Formula:C₁₄H₁₃Cl₃F₃NO₂
Molecular Weight:390.617
Hs Code.:

Synonyms:N-((3E)-1-(benzyloxy)-5,5,5-trifluoropent-3-en-2-yl)-2,2,2-trichloroacetamide

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Chemical Property of N-((3E)-1-(benzyloxy)-5,5,5-trifluoropent-3-en-2-yl)-2,2,2-trichloroacetamide

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Technology Process of N-((3E)-1-(benzyloxy)-5,5,5-trifluoropent-3-en-2-yl)-2,2,2-trichloroacetamide

There total 2 articles about N-((3E)-1-(benzyloxy)-5,5,5-trifluoropent-3-en-2-yl)-2,2,2-trichloroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1415355-13-3
C₁₄H₁₃Cl₃F₃NO₂

: 545-06-2
trichloroacetonitrile

: 135502-51-1
(3E)-5-(benzyloxy)-1,1,1-trifluoropent-3-en-2-ol

: 1415354-90-3
N-((3E)-1-(benzyloxy)-5,5,5-trifluoropent-3-en-2-yl)-2,2,2-trichloroacetamide

Guidance literature:: trichloroacetonitrile; (3E)-5-(benzyloxy)-1,1,1-trifluoropent-3-en-2-ol; With 1,8-diazabicyclo[5.4.0]undec-7-ene; at 0 ℃; for 0.5h; Inert atmosphere;

C₁₄H₁₃Cl₃F₃NO₂; With dichloro bis(acetonitrile) palladium(II); In dichloromethane; at 40 ℃; for 4h; regioselective reaction; Reflux;
DOI:10.1016/j.tetlet.2012.10.045 DOI:10.1016/j.tetlet.2012.10.045

Reference yield:

: 69152-87-0
4-benzyloxycrotonaldehyde

: 1415354-90-3
N-((3E)-1-(benzyloxy)-5,5,5-trifluoropent-3-en-2-yl)-2,2,2-trichloroacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrabutyl ammonium fluoride; hydrogenchloride / tetrahydrofuran / 0 - 20 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 0.5 h / 0 °C / Inert atmosphere

2.2: 4 h / 40 °C / Reflux

With hydrogenchloride; tetrabutyl ammonium fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; 2.2: |Overman Rearrangement;
DOI:10.1016/j.tetlet.2012.10.045 DOI:10.1016/j.tetlet.2012.10.045