4-((1S,2R,6S,7R)-1,7-dimethyl-3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en4-yl)-2-trifluoromethyl-benzonitrile

Base Information

• Chemical Name: 4-((1S,2R,6S,7R)-1,7-dimethyl-3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en4-yl)-2-trifluoromethyl-benzonitrile
• CAS No.: 406224-37-1
• Molecular Formula: C₁₈H₁₃F₃N₂O₃
• Molecular Weight: 362.308

Synonyms:4-((1S,2R,6S,7R)-1,7-dimethyl-3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en4-yl)-2-trifluoromethyl-benzonitrile

Chemical Property of 4-((1S,2R,6S,7R)-1,7-dimethyl-3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en4-yl)-2-trifluoromethyl-benzonitrile

Chemical Property:

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Technology Process of 4-((1S,2R,6S,7R)-1,7-dimethyl-3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en4-yl)-2-trifluoromethyl-benzonitrile

There total 1 articles about 4-((1S,2R,6S,7R)-1,7-dimethyl-3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en4-yl)-2-trifluoromethyl-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,5-dimethylfuran (625-86-5) + 4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-2-(trifluoromethyl)benzonitrile (406224-65-5) → 4-((1S,2R,6S,7R)-1,7-dimethyl-3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.02,6]dec-8-en4-yl)-2-trifluoromethyl-benzonitrile (406224-37-1)

Guidance literature:

In toluene; at 60 ℃; for 3.5h;

Reference yield: 71.0%

4-((1S,2R,6S,7R)-1,7-dimethyl-3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.02,6]dec-8-en4-yl)-2-trifluoromethyl-benzonitrile (406224-37-1) → C18H15F3N2O4

Guidance literature:

4-((1S,2R,6S,7R)-1,7-dimethyl-3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en4-yl)-2-trifluoromethyl-benzonitrile; With borane-THF; at 0 ℃; for 0.5h;

With dihydrogen peroxide; at 0 ℃; for 0.5h; pH=7.2;

Reference yield: 37.0%

4-((1S,2R,6S,7R)-1,7-dimethyl-3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.02,6]dec-8-en4-yl)-2-trifluoromethyl-benzonitrile (406224-37-1) → 4-((1R,2R,6S,7S)-9-hydroxy-1,7-dimethyl-3,5-dioxo-11-oxa-4,9-diaza-tricyclo[5.3.1.02,6]undec-4-yl)-2-trifluoromethyl-benzonitrile

Guidance literature:

4-((1S,2R,6S,7R)-1,7-dimethyl-3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en4-yl)-2-trifluoromethyl-benzonitrile; With ozone; In methanol; 1,2-dichloro-ethane; at -70 ℃; for 4h;

With sodium cyanoborohydride; In methanol; 1,2-dichloro-ethane; at 5 - 20 ℃; for 0.833333h;

With water; hydroxylamine; sodium cyanoborohydride; sodium hydrogencarbonate; acetic acid; more than 3 stages;

upstream raw materials:

2,5-dimethylfuran

4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-2-(trifluoromethyl)benzonitrile

Downstream raw materials:

C₁₈H₁₃F₃N₂O₅

C₂₄H₂₁F₃N₄O₅S

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