Succinanilide

Base Information

• Chemical Name: Succinanilide
• CAS No.: 15510-09-5
• Molecular Formula: C16H16 N2 O2
• Molecular Weight: 268.315
• NSC Number: 112704
• DSSTox Substance ID: DTXSID80935129
• Nikkaji Number: J2.569.397C
• Wikidata: Q82911138
• ChEMBL ID: CHEMBL1332917
• Mol file: 15510-09-5.mol

Synonyms:Succinanilide;N,N'-diphenylbutanediamide;15510-09-5;n,n'-diphenylsuccinamide;SR-01000253056-2;Succinphenylamid;Butanediamide, N,N'-diphenyl-;Butanediamine, N,N'-diphenyl-;NSC112704;N-Phenyl-N'-phenylbutane-1,4-diamide;N,N''-diphenylsuccinamide;Butanediamide,N'-diphenyl-;Butanediamine,N'-diphenyl-;Cambridge id 7161771;N,N''-diphenylbutanediamide;Oprea1_175830;Oprea1_360589;cid_270325;SCHEMBL3342586;CHEMBL1332917;BDBM67457;DTXSID80935129;NOEOAZMRAXYIEK-UHFFFAOYSA-N;HMS1589B03;STK016683;AKOS000493242;NSC-112704;N~1~,N~4~-Diphenylbutanediimidic acid;SR-01000253056;SR-01000253056-1

Chemical Property of Succinanilide

Chemical Property:

• XLogP3: 2.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 268.121177757
• Heavy Atom Count: 20
• Complexity: 286

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)NC(=O)CCC(=O)NC2=CC=CC=C2

Technology Process of Succinanilide

There total 27 articles about Succinanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

succinoyl dichloride (543-20-4) + aniline (62-53-3) → Succinanilid (15510-09-5)

Guidance literature:

In pyridine; at 20 ℃; for 24h;

DOI:10.3390/50500714

Reference yield: 94.0%

1,4-di(1H-benzo[d][1,2,3]triazol-1-yl)butane-1,4-dione + aniline (62-53-3) → Succinanilid (15510-09-5)

Guidance literature:

In chloroform; at 80 ℃; for 0.166667h; microwave irradiation;

DOI:10.1021/jo052443x

Reference yield: 81.0%

aniline (62-53-3) + succinic acid diethyl ester (123-25-1) → Succinanilid (15510-09-5)

Guidance literature:

With 1-(3-sulfopropyl)pyridinium phosphotungstate; In neat (no solvent); at 140 ℃; for 1h; Microwave irradiation;

DOI:10.1016/j.tetlet.2015.05.118

upstream raw materials:

thiosuccinic acid-anhydride

aniline

succinic acid

2,4-bis(anilino)-1,3-diphenyl-1,3,2,4-diazadiphosphetidine

Downstream raw materials:

methanetrisulfonic acid

succinic acid

aniline

N-phenyl-succinamic acid

Refernces

• 1、 Fu, Renzhong,Yang, Yang,Ma, Yunsheng,Yang, Fei,Li, Jingjing,Chai, Wen,Wang, Quan,Yuan, Rongxin. "Microwave-promoted direct amidation of unactivated esters catalyzed by heteropolyanion-based ionic liquids under solvent-free conditions". supporting information. p. 4527 - 4531. Retrieved 2015/06/30.
• 2、 Yang, Wen-Chu,Sedlak, Miroslav,Regnier, Fred E.,Mosier, Nathan,Ho, Nancy,Adamec, Jiri. "Simultaneous quantification of metabolites involved in central carbon and energy metabolism using reversed-phase liquid chromatography-mass spectrometry and in vitro 13C labeling". experimental part. p. 9508 - 9516. Retrieved 2009/07/11.