5-(3-Nitro-benzoyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid methyl ester

Base Information

• Chemical Name: 5-(3-Nitro-benzoyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid methyl ester
• CAS No.: 96327-03-6
• Molecular Formula: C₁₆H₁₄N₂O₅
• Molecular Weight: 314.298

Synonyms:5-(3-Nitro-benzoyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid methyl ester

Chemical Property of 5-(3-Nitro-benzoyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid methyl ester

Chemical Property:

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Technology Process of 5-(3-Nitro-benzoyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid methyl ester

There total 1 articles about 5-(3-Nitro-benzoyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

methyl 2,3-dihydro-1H-pyrrolo[1,2-a]-pyrrole-1-carboxylate (76786-65-7) + m-nitrobenzoic acid chloride (121-90-4) → 5-(3-Nitro-benzoyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid methyl ester (96327-03-6)

Guidance literature:

In toluene; for 20h; Heating;

DOI:10.1021/jm00146a011

Reference yield: 96.0%

5-(3-Nitro-benzoyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid methyl ester (96327-03-6) → methyl 5-(3-aminobenzoyl)-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1-carboxylate (96327-05-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 0.5h; under 2068.6 Torr; Ambient temperature;

DOI:10.1021/jm00146a011

Reference yield: 39.0%

5-(3-Nitro-benzoyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid methyl ester (96327-03-6) → 5-(3-Nitro-benzoyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid (96327-45-6)

Guidance literature:

With potassium hydroxide; In methanol; water; for 3h; Heating;

DOI:10.1021/jm00146a011

upstream raw materials:

methyl 2,3-dihydro-1H-pyrrolo[1,2-a]-pyrrole-1-carboxylate

m-nitrobenzoic acid chloride

Downstream raw materials:

methyl 5-(3-aminobenzoyl)-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1-carboxylate

5-(3-Nitro-benzoyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid

5-(3-Isobutyrylamino-benzoyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid

methyl 5-(3-isobutyramidobenzoyl)-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1-carboxylate

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