3-Piperidinecarboxylicacid, 4-oxo-1-(2-phenylethyl)-, ethyl ester

Base Information

• Chemical Name: 3-Piperidinecarboxylicacid, 4-oxo-1-(2-phenylethyl)-, ethyl ester
• CAS No.: 56547-83-2
• Molecular Formula: C16H21 N O3
• Molecular Weight: 275.348

Synonyms:Nipecoticacid, 4-oxo-1-phenethyl-, ethyl ester (6CI); NSC 139643

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Chemical Property of 3-Piperidinecarboxylicacid, 4-oxo-1-(2-phenylethyl)-, ethyl ester

Chemical Property:

• Boiling Point: 400.5°Cat760mmHg
• Flash Point: 196°C
• Density: 1.117g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Piperidinecarboxylicacid, 4-oxo-1-(2-phenylethyl)-, ethyl ester

There total 2 articles about 3-Piperidinecarboxylicacid, 4-oxo-1-(2-phenylethyl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3,3'-phenethylimino-di-propionic acid diethyl ester (57958-47-1) → ethyl 4-oxo-1-(2-phenylethyl)piperidine-3-carboxylate (56547-83-2)

Guidance literature:

With titanium tetrachloride; triethylamine; In dichloromethane; at -15 - -5 ℃; for 5h;

DOI:10.1080/00397919508010804

Reference yield:

→ ethyl 4-oxo-1-(2-phenylethyl)piperidine-3-carboxylate (56547-83-2)

Guidance literature:

/BRN= 144582/;

Reference yield: 86.0%

ethyl 4-oxo-1-(2-phenylethyl)piperidine-3-carboxylate (56547-83-2) + acrylonitrile (107-13-1,25014-41-9) → 3-(3-ethoxycarbonyl-4-oxo-1-(2-phenylethyl)-3-piperidinyl)propionitrile (72394-38-8)

Guidance literature:

With potassium hydroxide; In 1,4-dioxane; water; Ambient temperature;

upstream raw materials:

3,3'-phenethylimino-di-propionic acid diethyl ester

Downstream raw materials:

3-(3-ethoxycarbonyl-4-oxo-1-(2-phenylethyl)-3-piperidinyl)propionitrile

2-phenylethylamine hydrochloride

6-Phenethyl-octahydro-pyrano[3,2-c]pyridin-2-one; hydrochloride

ethyl 3-(4-hydroxy-1-(2-phenylethyl)-3-piperidinyl)propionate hydrochloride