methyl trans-4-(1-((5-chloro-2-fluoro-4-(1-methyl-3-indolylcarbonylamino)phenyl)acetyl)-(2S)-pyrrolidinylmethoxy)-1-cyclohexanecarboxylate

Base Information

Chemical Name:methyl trans-4-(1-((5-chloro-2-fluoro-4-(1-methyl-3-indolylcarbonylamino)phenyl)acetyl)-(2S)-pyrrolidinylmethoxy)-1-cyclohexanecarboxylate
CAS No.:441716-71-8
Molecular Formula:C₃₁H₃₅ClFN₃O₅
Molecular Weight:584.087
Hs Code.:

Synonyms:methyl trans-4-(1-((5-chloro-2-fluoro-4-(1-methyl-3-indolylcarbonylamino)phenyl)acetyl)-(2S)-pyrrolidinylmethoxy)-1-cyclohexanecarboxylate

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Chemical Property of methyl trans-4-(1-((5-chloro-2-fluoro-4-(1-methyl-3-indolylcarbonylamino)phenyl)acetyl)-(2S)-pyrrolidinylmethoxy)-1-cyclohexanecarboxylate

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Technology Process of methyl trans-4-(1-((5-chloro-2-fluoro-4-(1-methyl-3-indolylcarbonylamino)phenyl)acetyl)-(2S)-pyrrolidinylmethoxy)-1-cyclohexanecarboxylate

There total 2 articles about methyl trans-4-(1-((5-chloro-2-fluoro-4-(1-methyl-3-indolylcarbonylamino)phenyl)acetyl)-(2S)-pyrrolidinylmethoxy)-1-cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 441716-71-8
methyl trans-4-(1-((5-chloro-2-fluoro-4-(1-methyl-3-indolylcarbonylamino)phenyl)acetyl)-(2S)-pyrrolidinylmethoxy)-1-cyclohexanecarboxylate

Guidance literature:

Reference yield:

: [5-chloro-2-fluoro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetic acid

: 441769-29-5
methyl trans-4-[(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

: 441716-71-8
methyl trans-4-(1-((5-chloro-2-fluoro-4-(1-methyl-3-indolylcarbonylamino)phenyl)acetyl)-(2S)-pyrrolidinylmethoxy)-1-cyclohexanecarboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1021/jm901154c

Reference yield:

: 441716-71-8
methyl trans-4-(1-((5-chloro-2-fluoro-4-(1-methyl-3-indolylcarbonylamino)phenyl)acetyl)-(2S)-pyrrolidinylmethoxy)-1-cyclohexanecarboxylate

: 441713-00-4
trans-4-[1-[[5-chloro-2-fluoro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid

Guidance literature:: methyl trans-4-(1-((5-chloro-2-fluoro-4-(1-methyl-3-indolylcarbonylamino)phenyl)acetyl)-(2S)-pyrrolidinylmethoxy)-1-cyclohexanecarboxylate; With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; water; Cooling with ice;
DOI:10.1021/jm901154c