2-amino-4-(2-chlorophenyl)-7-methoxy-4H-chromene-3-carbonitrile

Base Information

• Chemical Name: 2-amino-4-(2-chlorophenyl)-7-methoxy-4H-chromene-3-carbonitrile
• CAS No.: 1649471-86-2
• Molecular Formula: C₁₇H₁₃ClN₂O₂
• Molecular Weight: 312.755
• Mol file: 1649471-86-2.mol

Synonyms:2-amino-4-(2-chlorophenyl)-7-methoxy-4H-chromene-3-carbonitrile

Chemical Property of 2-amino-4-(2-chlorophenyl)-7-methoxy-4H-chromene-3-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-amino-4-(2-chlorophenyl)-7-methoxy-4H-chromene-3-carbonitrile

There total 2 articles about 2-amino-4-(2-chlorophenyl)-7-methoxy-4H-chromene-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

O-methylresorcine (150-19-6) + o-chlorobenzylidene malononitrile (2698-41-1) → 2-amino-4-(2-chlorophenyl)-7-methoxy-4H-chromene-3-carbonitrile (1649471-86-2)

Guidance literature:

With triethylamine; In ethanol; water; at 20 ℃; for 2h;

DOI:10.1134/S1070428017010080

Reference yield:

2-chloro-benzaldehyde (89-98-5) → 2-amino-4-(2-chlorophenyl)-7-methoxy-4H-chromene-3-carbonitrile (1649471-86-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium fluoride dihydrate / ethanol / 60 °C

2: piperidine / ethanol / 60 °C

With piperidine; potassium fluoride dihydrate; In ethanol;

DOI:10.1002/jhet.2010

Reference yield: 74.0%

2-amino-4-(2-chlorophenyl)-7-methoxy-4H-chromene-3-carbonitrile (1649471-86-2) → 4-(2-chlorophenyl)-7-methoxy-2-oxo-2H-chromene-3-carbonitrile

Guidance literature:

With chromium(VI) oxide; acetic acid; at 60 ℃; for 0.666667h;

DOI:10.1134/S1070428017010080

upstream raw materials:

O-methylresorcine

o-chlorobenzylidene malononitrile

2-chloro-benzaldehyde

Downstream raw materials:

11-amino-12-(2-chlorophenyl)-3-methoxy-8-phenyl-8,9-dihydro-7H-chromeno[2,3-b]quinolin-10(12H)-one