4-cyclopentylamino-2-(4-(4-methylpiperazin-1-yl)phenylamino)-5-aminopyrimidine

Base Information

• Chemical Name: 4-cyclopentylamino-2-(4-(4-methylpiperazin-1-yl)phenylamino)-5-aminopyrimidine
• CAS No.: 330551-07-0
• Molecular Formula: C₂₀H₂₉N₇
• Molecular Weight: 367.497

Synonyms:4-cyclopentylamino-2-(4-(4-methylpiperazin-1-yl)phenylamino)-5-aminopyrimidine

Chemical Property of 4-cyclopentylamino-2-(4-(4-methylpiperazin-1-yl)phenylamino)-5-aminopyrimidine

Chemical Property:

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Technology Process of 4-cyclopentylamino-2-(4-(4-methylpiperazin-1-yl)phenylamino)-5-aminopyrimidine

There total 8 articles about 4-cyclopentylamino-2-(4-(4-methylpiperazin-1-yl)phenylamino)-5-aminopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N4-cyclopentyl-N2-(4-(4-methylpiperazin-1-yl)phenyl)-5-nitropyrimidine-2,4-diamine (330550-98-6) → 4-cyclopentylamino-2-(4-(4-methylpiperazin-1-yl)phenylamino)-5-aminopyrimidine (330551-07-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 60 ℃; for 14h; under 760.051 Torr;

DOI:10.1016/j.ejmech.2015.03.044

Reference yield:

Cyclopentamine (1003-03-8) → 4-cyclopentylamino-2-(4-(4-methylpiperazin-1-yl)phenylamino)-5-aminopyrimidine (330551-07-0)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / -60 °C

2: butan-1-ol / 5 h / 90 °C

3: hydrogen; palladium 10% on activated carbon / methanol / 6 h / 50 °C / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; butan-1-ol;

DOI:10.1021/jm301365e

Reference yield:

2-chloro-N-cyclopentyl-5-nitropyrimidin-4-amine (330550-92-0) → 4-cyclopentylamino-2-(4-(4-methylpiperazin-1-yl)phenylamino)-5-aminopyrimidine (330551-07-0)

Guidance literature:

Multi-step reaction with 2 steps

1: butan-1-ol / 5 h / 90 °C

2: hydrogen; palladium 10% on activated carbon / methanol / 6 h / 50 °C / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; In methanol; butan-1-ol;

DOI:10.1021/jm301365e

upstream raw materials:

N⁴-cyclopentyl-N²-(4-(4-methylpiperazin-1-yl)phenyl)-5-nitropyrimidine-2,4-diamine

1-methyl-piperazine

2-chloro-N-cyclopentyl-5-nitropyrimidin-4-amine

Cyclopentamine

Downstream raw materials:

8-Cyclopentyl-6methyl-2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]-8H-pteridin-7-one

8-Cyclopentyl-2-[[4-(4methylpiperazin-1-yl)phenyl]amino]-8H-pteridin-7-one

9-cyclopentyl-N-(4-(4-methylpiperazin-1-yl)phenyl)-8-phenylamino-9H-purin-2 -amine

8-(3-nitrophenylamino)-9-cyclopentyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)-9H-purine

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