(2,3-dihydro-benzo[1,4]dioxin-6-yl)-[4-(4-isopropyl-phenyl)-6-propargyloxy-quinazolin-2-yl]-methanone

Base Information

Chemical Name:(2,3-dihydro-benzo[1,4]dioxin-6-yl)-[4-(4-isopropyl-phenyl)-6-propargyloxy-quinazolin-2-yl]-methanone
CAS No.:1042131-16-7
Molecular Formula:C₂₉H₂₄N₂O₄
Molecular Weight:464.521
Hs Code.:

Synonyms:(2,3-dihydro-benzo[1,4]dioxin-6-yl)-[4-(4-isopropyl-phenyl)-6-propargyloxy-quinazolin-2-yl]-methanone

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Chemical Property of (2,3-dihydro-benzo[1,4]dioxin-6-yl)-[4-(4-isopropyl-phenyl)-6-propargyloxy-quinazolin-2-yl]-methanone

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Technology Process of (2,3-dihydro-benzo[1,4]dioxin-6-yl)-[4-(4-isopropyl-phenyl)-6-propargyloxy-quinazolin-2-yl]-methanone

There total 5 articles about (2,3-dihydro-benzo[1,4]dioxin-6-yl)-[4-(4-isopropyl-phenyl)-6-propargyloxy-quinazolin-2-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1042131-28-1
(2,3-dihydro-benzo[1,4]dioxin-6-yl)-[4-(4-isopropyl-phenyl)-6-propargyloxy-quinazolin-2-yl]-methanol

: 1042131-16-7
(2,3-dihydro-benzo[1,4]dioxin-6-yl)-[4-(4-isopropyl-phenyl)-6-propargyloxy-quinazolin-2-yl]-methanone

Guidance literature:: With Jones reagent; In acetone; at 20 ℃; for 0.25h;

Reference yield:

: 478964-94-2
(2-amino-5-propargyloxy-phenyl)-(4-isopropylphenyl)methanone

: 1042131-16-7
(2,3-dihydro-benzo[1,4]dioxin-6-yl)-[4-(4-isopropyl-phenyl)-6-propargyloxy-quinazolin-2-yl]-methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium acetate; oxygen / water; toluene / 72 h

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

3.1: Dess-Martin periodane / dichloromethane / 3 h

4.1: magnesium / tetrahydrofuran / 0.33 h / 60 °C

4.2: 1 h / 5 - 20 °C

5.1: Jones reagent / acetone / 0.25 h / 20 °C

With lithium aluminium tetrahydride; Jones reagent; ammonium acetate; oxygen; Dess-Martin periodane; magnesium; In tetrahydrofuran; dichloromethane; water; acetone; toluene;

Reference yield:

: 927201-06-7
4-(4-isopropyl-phenyl)-6-propargyloxy-quinazoline-2-carboxylic acid ethyl ester

: 1042131-16-7
(2,3-dihydro-benzo[1,4]dioxin-6-yl)-[4-(4-isopropyl-phenyl)-6-propargyloxy-quinazolin-2-yl]-methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

2.1: Dess-Martin periodane / dichloromethane / 3 h

3.1: magnesium / tetrahydrofuran / 0.33 h / 60 °C

3.2: 1 h / 5 - 20 °C

4.1: Jones reagent / acetone / 0.25 h / 20 °C

With lithium aluminium tetrahydride; Jones reagent; Dess-Martin periodane; magnesium; In tetrahydrofuran; dichloromethane; acetone;