4-vinylhex-5-enoic acid 4-methoxybenzylamide

Base Information

• Chemical Name: 4-vinylhex-5-enoic acid 4-methoxybenzylamide
• CAS No.: 1374353-65-7
• Molecular Formula: C₁₆H₂₁NO₂
• Molecular Weight: 259.348
• Mol file: 1374353-65-7.mol

Synonyms:4-vinylhex-5-enoic acid 4-methoxybenzylamide

Chemical Property of 4-vinylhex-5-enoic acid 4-methoxybenzylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-vinylhex-5-enoic acid 4-methoxybenzylamide

There total 2 articles about 4-vinylhex-5-enoic acid 4-methoxybenzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

6-iodomethyl-1-(4-methoxybenzyl)-2-oxo-5-vinylpiperidine + ethyl 2-bromomethyl-2-propenoate (17435-72-2) → 4-vinylhex-5-enoic acid 4-methoxybenzylamide (1374353-65-7) + 4-[1-(4-methoxybenzyl)-6-oxo-3-vinylpiperidin-2-yl]-2-methylenebutyric acid ethyl ester

Guidance literature:

6-iodomethyl-1-(4-methoxybenzyl)-2-oxo-5-vinylpiperidine; With chloro-trimethyl-silane; copper(l) cyanide; ethylene dibromide; lithium chloride; zinc; In N,N-dimethyl-formamide; at -55 - 0 ℃; for 0.166667h; Inert atmosphere;

ethyl 2-bromomethyl-2-propenoate; In N,N-dimethyl-formamide; at -55 - 20 ℃; for 16h; Inert atmosphere;

DOI:10.1039/c1ob06539d

Reference yield:

6-hydroxymethyl-1-(4-methoxybenzyl)-2-oxo-5-vinylpiperidine → 4-vinylhex-5-enoic acid 4-methoxybenzylamide (1374353-65-7) + 4-[1-(4-methoxybenzyl)-6-oxo-3-vinylpiperidin-2-yl]-2-methylenebutyric acid ethyl ester

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1H-imidazole; iodine; triphenylphosphine / tetrahydrofuran / 0.5 h / 70 °C

2.1: chloro-trimethyl-silane; copper(l) cyanide; ethylene dibromide; lithium chloride; zinc / N,N-dimethyl-formamide / 0.17 h / -55 - 0 °C / Inert atmosphere

2.2: 16 h / -55 - 20 °C / Inert atmosphere

With 1H-imidazole; chloro-trimethyl-silane; iodine; copper(l) cyanide; ethylene dibromide; triphenylphosphine; lithium chloride; zinc; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1039/c1ob06539d

upstream raw materials:

ethyl 2-bromomethyl-2-propenoate