methyl (R)-4-(benzo[d]thiazol-2-yl)-2-((2-methoxyphenyl)amino)-2-(trifluoromethyl)but-3-ynoate

Base Information

Chemical Name:methyl (R)-4-(benzo[d]thiazol-2-yl)-2-((2-methoxyphenyl)amino)-2-(trifluoromethyl)but-3-ynoate
CAS No.:1309593-04-1
Molecular Formula:C₂₀H₁₅F₃N₂O₃S
Molecular Weight:420.412
Hs Code.:

Synonyms:methyl (R)-4-(benzo[d]thiazol-2-yl)-2-((2-methoxyphenyl)amino)-2-(trifluoromethyl)but-3-ynoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (R)-4-(benzo[d]thiazol-2-yl)-2-((2-methoxyphenyl)amino)-2-(trifluoromethyl)but-3-ynoate

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Technology Process of methyl (R)-4-(benzo[d]thiazol-2-yl)-2-((2-methoxyphenyl)amino)-2-(trifluoromethyl)but-3-ynoate

There total 5 articles about methyl (R)-4-(benzo[d]thiazol-2-yl)-2-((2-methoxyphenyl)amino)-2-(trifluoromethyl)but-3-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1123-99-5
2-iodobenzothiazole

: 1309593-03-0
methyl (R)-2-((2-methoxyphenyl)amino)-2-(trifluoromethyl)but-3-ynoate

: 1309593-04-1
methyl (R)-4-(benzo[d]thiazol-2-yl)-2-((2-methoxyphenyl)amino)-2-(trifluoromethyl)but-3-ynoate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine; In tetrahydrofuran; at 45 ℃; for 5h; Inert atmosphere;
DOI:10.1039/c1cc10403a

Reference yield:

: 1309592-88-8
methyl 3,3,3-trifluoro-2-(2-methoxyphenylimino)propanoate

: 1309593-04-1
methyl (R)-4-(benzo[d]thiazol-2-yl)-2-((2-methoxyphenyl)amino)-2-(trifluoromethyl)but-3-ynoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dimethyl zinc(II) / toluene / 12 h / 20 °C / Inert atmosphere; Sealed tube

1.2: 2.5 h / 20 °C / Inert atmosphere

1.3: 48 h / 20 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 °C

3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diisopropylamine / tetrahydrofuran / 5 h / 45 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; dimethyl zinc(II); diisopropylamine; In tetrahydrofuran; toluene;
DOI:10.1039/c1cc10403a

Reference yield:

: 1309593-01-8
methyl (R)-2-(2-methoxyphenylamino)-2-(trifluoromethyl)-4-(trimethylsilyl)but-3-ynoate

: 1309593-04-1
methyl (R)-4-(benzo[d]thiazol-2-yl)-2-((2-methoxyphenyl)amino)-2-(trifluoromethyl)but-3-ynoate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 °C

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diisopropylamine / tetrahydrofuran / 5 h / 45 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; diisopropylamine; In tetrahydrofuran;
DOI:10.1039/c1cc10403a