Carbendazim

Base Information

• Chemical Name: Carbendazim
• CAS No.: 10605-21-7
• Deprecated CAS: 102040-01-7,105268-95-9,110342-67-1,39413-19-9,59758-95-1,63090-40-4,63278-70-6,212384-28-6,276680-08-1,1135441-26-7,1155875-94-7,1203557-88-3,105268-95-9,110342-67-1,1135441-26-7,1155875-94-7,1203557-88-3,212384-28-6,276680-08-1,39413-19-9,59758-95-1,63090-40-4,63278-70-6
• Molecular Formula: C₉H₉N₃O₂
• Molecular Weight: 191.189
• Hs Code.: 29339900
• European Community (EC) Number: 234-232-0
• ICSC Number: 1277
• NSC Number: 109874
• UN Number: 3082,3077
• UNII: H75J14AA89
• DSSTox Substance ID: DTXSID4024729
• Nikkaji Number: J3.120H
• Wikipedia: Carbendazim
• Wikidata: Q418607
• NCI Thesaurus Code: C1154
• Metabolomics Workbench ID: 45088
• ChEMBL ID: CHEMBL70971
• Mol file: 10605-21-7.mol

Synonyms:1h-benzimidazole-2-carbamic acid, methyl ester;2-(methoxycarbonylamino)benzimidazole;Bavistan;Bavistin;benzimidazolecarbamate methyl ester;carbendazim;carbendazim phosphate;carbendazin;carbendazine;carbendazole;carbendazyme;FB-642;FB642;G-665;IPO-1250;mecarzole;mecarzole monohydrochloride;mecarzole mononitrate;mecarzole monophosphate;mecarzole monophosphinate;mecarzole monosodium salt;mecarzole monosulfate;mecarzole triphosphinate;medamine;mekarzole;methoxybenzimidazole-2-carbamic acid;methyl 2-benzimidazil carbamate;methyl-2-benzimidazole carbamate;methyl-N-(2-benzimidazolyl)carbamate;methylbenzimidazole-2-ylcarbamate

Chemical Property of Carbendazim

Chemical Property:

• Appearance/Colour: light gray or beige powder
• Vapor Pressure: 1.5 x 10-4 Pa (25 °C)
• Melting Point: >300 °C(lit.)
• Refractive Index: 1.654
• Boiling Point: 409oC
• PKA: 4.48(at 25℃)
• Flash Point: 11 °C
• PSA: 67.01000
• Density: 1.421 g/cm³
• LogP: 1.81420
• Storage Temp.: APPROX 4°C
• Solubility.: pyridine: soluble1%, clear, very faintly brownish-yellow
• Water Solubility.: <0.1 g/100 mL at 21℃
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 191.069476538
• Heavy Atom Count: 14
• Complexity: 222
• Transport DOT Label: Class 9

Purity/Quality:

≥98.5% ^*data from raw suppliers

TNFRSF17 ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T,N,F
• Hazard Codes: T,N,F,Xn
• Statements: 46-60-61-50/53-39/23/24/25-23/24/25-11-52/53
• Safety Statements: 53-45-60-61-36/37-16

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Pesticides -> Fungicides
• Canonical SMILES: COC(=O)NC1=NC2=CC=CC=C2N1
• Recent ClinicalTrials: Carbendazim in Treating Patients With Advanced Solid Tumors or Lymphoma
• Recent EU Clinical Trials: Disease activity controlled dose escalating study to assess the efficacy, and safety of treatment with bilastine 20 mg, 40 mg and 80 mg in chronic spontaneous urticaria.
• Inhalation Risk: Evaporation at 20 °C is negligible; a harmful concentration of airborne particles can, however, be reached quickly on spraying or when dispersed, especially if powdered.
• Effects of Long Term Exposure: Animal tests show that this substance possibly causes toxicity to human reproduction or development.
• Description: Carbendazim is the degradation product and active ingredient of the carbamate fungicide benomyl. Carbendazim (100 μM) disrupts the growth of S. cerevisiae by inhibiting microtubule polymerization. It impairs meiosis and steroidogenesis in an ex vivo rat model of seminiferous tubules and increases prostate weight in rats when administered at a dose of 100 mg/kg but does not affect other testosterone-dependent or estrogen-dependent tissues.
• Uses: Carbendazim is the most widely used active ingredient in the benzimidazole class of fungicides. It is a systemic fungicide with both protective and curative activities against a wide range of fungal diseases, especially caused by most Ascomycetes spp. and some Basidiomycetes and Deuteromycetes spp. in a wide variety of crop and ornamental uses.