tert-butyl N-(diphenylmethylidene)-2-nitro-3-(trifluoromethyl)-L-phenylalaninate

Base Information

Chemical Name:tert-butyl N-(diphenylmethylidene)-2-nitro-3-(trifluoromethyl)-L-phenylalaninate
CAS No.:1258546-70-1
Molecular Formula:C₂₇H₂₅F₃N₂O₄
Molecular Weight:498.502
Hs Code.:

Synonyms:tert-butyl N-(diphenylmethylidene)-2-nitro-3-(trifluoromethyl)-L-phenylalaninate

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Chemical Property of tert-butyl N-(diphenylmethylidene)-2-nitro-3-(trifluoromethyl)-L-phenylalaninate

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Technology Process of tert-butyl N-(diphenylmethylidene)-2-nitro-3-(trifluoromethyl)-L-phenylalaninate

There total 4 articles about tert-butyl N-(diphenylmethylidene)-2-nitro-3-(trifluoromethyl)-L-phenylalaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1227582-31-1
1-(bromomethyl)-2-nitro-3-(trifluoromethyl)benzene

: 81477-94-3
N-(diphenylmethylene)glycine tert-butyl ester

: 1258546-70-1
tert-butyl N-(diphenylmethylidene)-2-nitro-3-(trifluoromethyl)-L-phenylalaninate

Guidance literature:: With (-)-(O)-⁽⁹⁾-allyl-N-(9-anthracenylmethyl)cinchodinium bromide; caesium hydroxide monohydrate; In dichloromethane; at -30 ℃; for 18h; optical yield given as %ee; enantioselective reaction;
DOI:10.1021/jo200530j

Reference yield:

: 1227511-82-1
[2-nitro-3-(trifluoromethyl)phenyl]methanol

: 1258546-70-1
tert-butyl N-(diphenylmethylidene)-2-nitro-3-(trifluoromethyl)-L-phenylalaninate

Guidance literature:: Multi-step reaction with 2 steps

1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0.33 h / 0 °C

2: caesium hydroxide monohydrate; (-)-(O)-⁽⁹⁾-allyl-N-(9-anthracenylmethyl)cinchodinium bromide / dichloromethane / 18 h / -30 °C

With (-)-(O)-⁽⁹⁾-allyl-N-(9-anthracenylmethyl)cinchodinium bromide; caesium hydroxide monohydrate; carbon tetrabromide; triphenylphosphine; In dichloromethane;
DOI:10.1021/jo200530j

Reference yield:

: 1227581-78-3
2-nitro-3-(trifluoromethyl)benzoic acid

: 1258546-70-1
tert-butyl N-(diphenylmethylidene)-2-nitro-3-(trifluoromethyl)-L-phenylalaninate

Guidance literature:: Multi-step reaction with 3 steps

1: boron fluoride-dimethyl sulfide complex / tetrahydrofuran / 0 - 60 °C

2: carbon tetrabromide; triphenylphosphine / dichloromethane / 0.33 h / 0 °C

3: caesium hydroxide monohydrate; (-)-(O)-⁽⁹⁾-allyl-N-(9-anthracenylmethyl)cinchodinium bromide / dichloromethane / 18 h / -30 °C

With (-)-(O)-⁽⁹⁾-allyl-N-(9-anthracenylmethyl)cinchodinium bromide; caesium hydroxide monohydrate; carbon tetrabromide; boron fluoride-dimethyl sulfide complex; triphenylphosphine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo200530j