tert-butyl 3-(4-fluoro-3-(1-methyl-1H-pyrazol-4-yl)phenethoxy)propanoate

Base Information

Chemical Name:tert-butyl 3-(4-fluoro-3-(1-methyl-1H-pyrazol-4-yl)phenethoxy)propanoate
CAS No.:1201640-88-1
Molecular Formula:C₁₉H₂₅FN₂O₃
Molecular Weight:348.418
Hs Code.:

Synonyms:tert-butyl 3-(4-fluoro-3-(1-methyl-1H-pyrazol-4-yl)phenethoxy)propanoate

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Chemical Property of tert-butyl 3-(4-fluoro-3-(1-methyl-1H-pyrazol-4-yl)phenethoxy)propanoate

Chemical Property:

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Technology Process of tert-butyl 3-(4-fluoro-3-(1-methyl-1H-pyrazol-4-yl)phenethoxy)propanoate

There total 4 articles about tert-butyl 3-(4-fluoro-3-(1-methyl-1H-pyrazol-4-yl)phenethoxy)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 1201640-87-0
2-(4-fluoro-3-(1-methyl-1H-pyrazol-4-yl)phenyl)ethanol

: 1201640-88-1
tert-butyl 3-(4-fluoro-3-(1-methyl-1H-pyrazol-4-yl)phenethoxy)propanoate

Guidance literature:: With N-benzyl-trimethylammonium hydroxide; at 20 ℃; for 1h;

Reference yield:

: 885681-61-8
methyl 2-(3-bromo-4-fluoro-phenyl)acetate

: 1201640-88-1
tert-butyl 3-(4-fluoro-3-(1-methyl-1H-pyrazol-4-yl)phenethoxy)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / water; acetonitrile / 0.42 h / 80 °C

2: diisobutylaluminium hydride / dichloromethane / Reflux

3: N-benzyl-trimethylammonium hydroxide / 1 h / 20 °C

With N-benzyl-trimethylammonium hydroxide; diisobutylaluminium hydride; potassium carbonate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In dichloromethane; water; acetonitrile; 1: Suzuki Coupling;

Reference yield:

: 194019-11-9
2-(3-bromo-4-fluorophenyl)acetic acid

: 1201640-88-1
tert-butyl 3-(4-fluoro-3-(1-methyl-1H-pyrazol-4-yl)phenethoxy)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: methanol / diethyl ether; dichloromethane / 0.17 h / Cooling with ice

2: potassium carbonate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / water; acetonitrile / 0.42 h / 80 °C

3: diisobutylaluminium hydride / dichloromethane / Reflux

4: N-benzyl-trimethylammonium hydroxide / 1 h / 20 °C

With methanol; N-benzyl-trimethylammonium hydroxide; diisobutylaluminium hydride; potassium carbonate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In diethyl ether; dichloromethane; water; acetonitrile; 2: Suzuki Coupling;