(S)-1-(3-(7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)piperidin-1-yl)-2-(3-chloro-5-fluorophenylamino)ethanone

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Chemical Name:(S)-1-(3-(7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)piperidin-1-yl)-2-(3-chloro-5-fluorophenylamino)ethanone
CAS No.:1374239-23-2
Molecular Formula:C₁₉H₁₉ClFN₅O₂
Molecular Weight:403.844
Hs Code.:

Synonyms:(S)-1-(3-(7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)piperidin-1-yl)-2-(3-chloro-5-fluorophenylamino)ethanone

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Chemical Property of (S)-1-(3-(7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)piperidin-1-yl)-2-(3-chloro-5-fluorophenylamino)ethanone

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Technology Process of (S)-1-(3-(7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)piperidin-1-yl)-2-(3-chloro-5-fluorophenylamino)ethanone

There total 5 articles about (S)-1-(3-(7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)piperidin-1-yl)-2-(3-chloro-5-fluorophenylamino)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 1374243-73-8
2-(3-chloro-5-fluorophenylamino)acetic acid

: (S)-4-(piperidine-3-yloxy)-7H-pyrrolo[2,3-d]pyrimidine hydrochloride

: 1374239-23-2
(S)-1-(3-(7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)piperidin-1-yl)-2-(3-chloro-5-fluorophenylamino)ethanone

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 143900-44-1
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

: 1374239-23-2
(S)-1-(3-(7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)piperidin-1-yl)-2-(3-chloro-5-fluorophenylamino)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 1.5 h / 20 °C / Inert atmosphere

1.2: 20 - 50 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / Reflux

3.1: hydrogenchloride / 1,4-dioxane / 0.5 h

4.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0 - 20 °C

With hydrogenchloride; tetrabutyl ammonium fluoride; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 941685-26-3
4-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine

: 1374239-23-2
(S)-1-(3-(7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)piperidin-1-yl)-2-(3-chloro-5-fluorophenylamino)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 1.5 h / 20 °C / Inert atmosphere

1.2: 20 - 50 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / Reflux

3.1: hydrogenchloride / 1,4-dioxane / 0.5 h

4.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0 - 20 °C

With hydrogenchloride; tetrabutyl ammonium fluoride; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;