ethyl 2-methyl-2-[(4-{[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)amino]methyl}phenyl)oxy]propanoate

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Chemical Name:ethyl 2-methyl-2-[(4-{[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)amino]methyl}phenyl)oxy]propanoate
CAS No.:929693-62-9
Molecular Formula:C₂₅H₂₇F₃N₂O₃S
Molecular Weight:492.562
Hs Code.:

Synonyms:ethyl 2-methyl-2-[(4-{[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)amino]methyl}phenyl)oxy]propanoate

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Chemical Property of ethyl 2-methyl-2-[(4-{[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)amino]methyl}phenyl)oxy]propanoate

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Technology Process of ethyl 2-methyl-2-[(4-{[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)amino]methyl}phenyl)oxy]propanoate

There total 7 articles about ethyl 2-methyl-2-[(4-{[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)amino]methyl}phenyl)oxy]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 438577-61-8
4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carbaldehyde

: 55458-83-8
ethyl 2-{[4-(aminomethyl)phenyl]oxy}-2-methylpropanoate

: 929693-62-9
ethyl 2-methyl-2-[(4-{[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)amino]methyl}phenyl)oxy]propanoate

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 24h;
DOI:10.1021/jm058056x

Reference yield:

: 175277-03-9
4-methyl-2-[4-(trifluoromethyl)phenyl]thiazole-5-carboxylic acid ethyl ester

: 929693-62-9
ethyl 2-methyl-2-[(4-{[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)amino]methyl}phenyl)oxy]propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 80.2 g / LiAlH₄ / tetrahydrofuran / 1.3 h / 20 °C

2: 62.5 percent / PCC / CH₂Cl₂ / 3 h / 20 °C

3: 13 percent / NaBH(OAc)3; AcOH / 1,2-dichloro-ethane / 24 h / 20 °C

With lithium aluminium tetrahydride; sodium tris(acetoxy)borohydride; acetic acid; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jm058056x

Reference yield:

: 600-00-0
ethyl 2-bromoisobutyrate

: 929693-62-9
ethyl 2-methyl-2-[(4-{[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)amino]methyl}phenyl)oxy]propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / dimethylformamide / 0.5 h / 20 °C

1.2: dimethylformamide / 20 - 80 °C

2.1: H₂; AcOH / Pd/C / ethanol / 8 h / 20 °C / 1500.12 Torr

3.1: 13 percent / NaBH(OAc)3; AcOH / 1,2-dichloro-ethane / 24 h / 20 °C

With hydrogen; sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; palladium on activated charcoal; In ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm058056x