(5R,6R,7R)-7-Methoxymethoxy-1-p-tolylsulfanyl-6-vinyl-spiro[4.5]dec-1-ene

Base Information

Chemical Name:(5R,6R,7R)-7-Methoxymethoxy-1-p-tolylsulfanyl-6-vinyl-spiro[4.5]dec-1-ene
CAS No.:158234-06-1
Molecular Formula:C₂₁H₂₈O₂S
Molecular Weight:344.518
Hs Code.:

Synonyms:(5R,6R,7R)-7-Methoxymethoxy-1-p-tolylsulfanyl-6-vinyl-spiro[4.5]dec-1-ene

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Chemical Property of (5R,6R,7R)-7-Methoxymethoxy-1-p-tolylsulfanyl-6-vinyl-spiro[4.5]dec-1-ene

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Technology Process of (5R,6R,7R)-7-Methoxymethoxy-1-p-tolylsulfanyl-6-vinyl-spiro[4.5]dec-1-ene

There total 2 articles about (5R,6R,7R)-7-Methoxymethoxy-1-p-tolylsulfanyl-6-vinyl-spiro[4.5]dec-1-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 107-30-2
chloromethyl methyl ether

: 158234-04-9
(5R,6R,7R)-1-p-Tolylsulfanyl-6-vinyl-spiro[4.5]dec-1-en-7-ol

: 158234-06-1
(5R,6R,7R)-7-Methoxymethoxy-1-p-tolylsulfanyl-6-vinyl-spiro[4.5]dec-1-ene

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 10h; Ambient temperature;
DOI:10.1039/c39940001835

Reference yield:

: 4-[1-((E)-3-Hydroxy-propenyl)-2-p-tolylsulfanyl-cyclopent-2-enyl]-butyraldehyde

: 158234-06-1
(5R,6R,7R)-7-Methoxymethoxy-1-p-tolylsulfanyl-6-vinyl-spiro[4.5]dec-1-ene

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / SnCl₂ / 10 molpercent PdCl₂(PhCN)2 / tetrahydrofuran; H₂O / 24 h / Ambient temperature

2: 89 percent / iPr₂NEt, DMAP / CH₂Cl₂ / 10 h / Ambient temperature

With dmap; N-ethyl-N,N-diisopropylamine; tin(ll) chloride; bis(benzonitrile)palladium(II) dichloride; In tetrahydrofuran; dichloromethane; water;
DOI:10.1039/c39940001835

Reference yield:

: 158234-06-1
(5R,6R,7R)-7-Methoxymethoxy-1-p-tolylsulfanyl-6-vinyl-spiro[4.5]dec-1-ene

: 158234-01-6
(5R,6R,7R)-6-Butyl-7-methoxymethoxy-1-p-tolylsulfanyl-spiro[4.5]dec-1-ene

Guidance literature:: Multi-step reaction with 3 steps

1: 1) 9-BBN dimer, 2) H₂O₂, NaOH / 1) THF, r.t., 12 h, 2) 0 deg C, 1 h

2: 80 percent / pyridine, DMAP / CH₂Cl₂ / 1 h / Ambient temperature

3: 74 percent / diethyl ether / 2 h / -40 °C

With pyridine; dmap; sodium hydroxide; dihydrogen peroxide; dimeric 9-borabicyclo[3.3.1]nonane; In diethyl ether; dichloromethane;
DOI:10.1039/c39940001835