{(1R,2R)-2-[(2R,4R,5S,6S)-6-{(1R,3R)-3-Benzyloxy-1-methyl-3-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-butyl}-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-ethyl-propoxy}-tert-butyl-dimethyl-silane

Base Information

• Chemical Name: {(1R,2R)-2-[(2R,4R,5S,6S)-6-{(1R,3R)-3-Benzyloxy-1-methyl-3-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-butyl}-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-ethyl-propoxy}-tert-butyl-dimethyl-silane
• CAS No.: 114182-41-1
• Molecular Formula: C₄₆H₇₄O₇Si
• Molecular Weight: 767.175
• Mol file: 114182-41-1.mol

Synonyms:{(1R,2R)-2-[(2R,4R,5S,6S)-6-{(1R,3R)-3-Benzyloxy-1-methyl-3-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-butyl}-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-ethyl-propoxy}-tert-butyl-dimethyl-silane

Chemical Property of {(1R,2R)-2-[(2R,4R,5S,6S)-6-{(1R,3R)-3-Benzyloxy-1-methyl-3-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-butyl}-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-ethyl-propoxy}-tert-butyl-dimethyl-silane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {(1R,2R)-2-[(2R,4R,5S,6S)-6-{(1R,3R)-3-Benzyloxy-1-methyl-3-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-butyl}-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-ethyl-propoxy}-tert-butyl-dimethyl-silane

There total 26 articles about {(1R,2R)-2-[(2R,4R,5S,6S)-6-{(1R,3R)-3-Benzyloxy-1-methyl-3-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-butyl}-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-ethyl-propoxy}-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

p-Anisaldehyde dimethyl acetal (2186-92-7) + (2R,4R,5S,6S,7R,8R,9R)-2-Benzyloxy-9-(tert-butyl-dimethyl-silanyloxy)-4,6,8-trimethyl-2-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-undecane-5,7-diol (114114-28-2) → {(1R,2R)-2-[(2R,4R,5S,6S)-6-{(1R,3R)-3-Benzyloxy-1-methyl-3-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-butyl}-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-ethyl-propoxy}-tert-butyl-dimethyl-silane (114182-41-1)

Guidance literature:

With toluene-4-sulfonic acid;

DOI:10.1016/S0040-4039(00)96400-1

Reference yield: 55.0%

p-Anisaldehyde dimethyl acetal (2186-92-7) + (2R,4R,5S,6S,7R,8R,9R)-2-Benzyloxy-7-tert-butoxy-9-(tert-butyl-dimethyl-silanyloxy)-4,6,8-trimethyl-2-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-undecan-5-ol → {(1R,2R)-2-[(4R,5S,6S)-6-{(1R,3R)-3-Benzyloxy-1-methyl-3-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-butyl}-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-ethyl-propoxy}-tert-butyl-dimethyl-silane (114137-90-5,114182-41-1)

Guidance literature:

toluene-4-sulfonic acid; In dichloromethane; for 0.5h;

DOI:10.1007/BF00958059

Reference yield: 23.0%

1-methoxy-4-(methoxymethyl)benzene (1515-81-7) + (2R,4R,5R,6S,7R,8R,9R)-2-Benzyloxy-9-(tert-butyl-dimethyl-silanyloxy)-4,6,8-trimethyl-2-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-undecane-5,7-diol (114181-56-5) → {(1R,2R)-2-[(2R,4R,5S,6R)-6-{(1R,3R)-3-Benzyloxy-1-methyl-3-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-butyl}-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-ethyl-propoxy}-tert-butyl-dimethyl-silane (114137-90-5,114182-41-1)

Guidance literature:

With 3 A molecular sieve; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; for 0.333333h; Ambient temperature;

DOI:10.1016/S0040-4020(01)96140-X

upstream raw materials:

p-Anisaldehyde dimethyl acetal

1-methoxy-4-(methoxymethyl)benzene

(2R,4R,5R,6S,7R,8R,9R)-2-Benzyloxy-9-(tert-butyl-dimethyl-silanyloxy)-4,6,8-trimethyl-2-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-undecane-5,7-diol

t-butyldimethylsiyl triflate

Downstream raw materials:

tert-Butyl-((1R,2R)-1-ethyl-2-{(3R,5R,6S,7S,8R)-1-(4-methoxy-phenyl)-3,5,7-trimethyl-3-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-2,9,10-trioxa-bicyclo[4.3.1]dec-8-yl}-propoxy)-dimethyl-silane

(2R,4R)-4-[(2R,4S,5S,6R)-6-[(1R,2R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-butyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-2-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-pentan-2-ol