tert-butyl 3-(2-nitroethyl)-2-oxo-3-phenylindoline-1-carboxylate

Base Information

• Chemical Name: tert-butyl 3-(2-nitroethyl)-2-oxo-3-phenylindoline-1-carboxylate
• CAS No.: 1636143-79-7
• Molecular Formula: C₂₁H₂₂N₂O₅
• Molecular Weight: 382.416
• Mol file: 1636143-79-7.mol

Synonyms:tert-butyl 3-(2-nitroethyl)-2-oxo-3-phenylindoline-1-carboxylate

Chemical Property of tert-butyl 3-(2-nitroethyl)-2-oxo-3-phenylindoline-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of tert-butyl 3-(2-nitroethyl)-2-oxo-3-phenylindoline-1-carboxylate

There total 2 articles about tert-butyl 3-(2-nitroethyl)-2-oxo-3-phenylindoline-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

di-tert-butyl dicarbonate (24424-99-5) + 3-(2-nitroethyl)-3-phenylindolin-2-one → tert-butyl 3-(2-nitroethyl)-2-oxo-3-phenylindoline-1-carboxylate (1636143-79-7)

Guidance literature:

With dmap; In dichloromethane; at 0 - 20 ℃; for 2.5h;

DOI:10.1021/jo501978j

Reference yield:

3-phenyloxindole (3456-79-9,123742-97-2) → tert-butyl 3-(2-nitroethyl)-2-oxo-3-phenylindoline-1-carboxylate (1636143-79-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 °C / Inert atmosphere

2: dmap / dichloromethane / 2.5 h / 0 - 20 °C

With dmap; triethylamine; In dichloromethane; 1: |Michael Addition;

DOI:10.1021/jo501978j

Reference yield: 55.0%

tert-butyl 3-(2-nitroethyl)-2-oxo-3-phenylindoline-1-carboxylate (1636143-79-7) → tert-butyl (2-(2-oxo-3-phenylpyrrolidin-3-yl)phenyl)carbamate

Guidance literature:

With sodium tetrahydroborate; nickel dichloride; In ethanol; at 20 ℃;

DOI:10.1021/jo501978j

upstream raw materials:

3-phenyloxindole

di-tert-butyl dicarbonate

Downstream raw materials:

C₂₁H₂₄N₂O₃