(3S,4R)-(+)-1-benzyloxycarbonyl-3-amino-4-hydroxypyrrolidine

Base Information

• Chemical Name: (3S,4R)-(+)-1-benzyloxycarbonyl-3-amino-4-hydroxypyrrolidine
• CAS No.: 1262383-54-9
• Molecular Formula: C₁₂H₁₆N₂O₃
• Molecular Weight: 236.271
• Mol file: 1262383-54-9.mol

Synonyms:(3S,4R)-(+)-1-benzyloxycarbonyl-3-amino-4-hydroxypyrrolidine

Chemical Property of (3S,4R)-(+)-1-benzyloxycarbonyl-3-amino-4-hydroxypyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S,4R)-(+)-1-benzyloxycarbonyl-3-amino-4-hydroxypyrrolidine

There total 10 articles about (3S,4R)-(+)-1-benzyloxycarbonyl-3-amino-4-hydroxypyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(3S,4R)-1-benzyloxycarbonyl-3-tert-butoxycarbonylamino-4-hydroxypyrrolidine → (3S,4R)-(+)-1-benzyloxycarbonyl-3-amino-4-hydroxypyrrolidine (1262383-54-9)

Guidance literature:

With hydrogenchloride; In ethanol; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2014.05.014

Reference yield:

C14H13F3N2O3 → (3S,4R)-(+)-1-benzyloxycarbonyl-3-amino-4-hydroxypyrrolidine (1262383-54-9)

Guidance literature:

With potassium carbonate; In methanol; water; at 20 ℃; for 24h;

Reference yield:

(±)-cis-1-benzyloxycarbonyl-3-tert-butoxycarbonylamino-4-hydroxypyrrolidine → (3S,4R)-(+)-1-benzyloxycarbonyl-3-amino-4-hydroxypyrrolidine (1262383-54-9)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 12 h / 20 °C

2: immobilized Candida antarctica Lipase B; water / tert-butyl methyl ether / 10 h / 30 °C / Enzymatic reaction

3: hydrogenchloride / ethanol / 2 h / 20 °C

With hydrogenchloride; immobilized Candida antarctica Lipase B; water; potassium carbonate; In ethanol; tert-butyl methyl ether; acetonitrile;

DOI:10.1016/j.bmc.2014.05.014

upstream raw materials:

1-carboxybenzyl-3-pyrrolidine