C₆₀H₇₃Cl₆N₂O₁₈P

Base Information

• Chemical Name: C₆₀H₇₃Cl₆N₂O₁₈P
• CAS No.: 206272-23-3
• Molecular Formula: C₆₀H₇₃Cl₆N₂O₁₈P
• Molecular Weight: 1353.93
• Mol file: 206272-23-3.mol

Synonyms:C₆₀H₇₃Cl₆N₂O₁₈P

Chemical Property of C₆₀H₇₃Cl₆N₂O₁₈P

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₆₀H₇₃Cl₆N₂O₁₈P

There total 18 articles about C₆₀H₇₃Cl₆N₂O₁₈P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

C64H77Cl6N2O20P (206272-22-2) → C60H73Cl6N2O18P (206272-23-3)

Guidance literature:

With formic acid; N-butylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1016/S0040-4020(98)00133-1

Reference yield:

allyl 4,6-O-benzylidene-2-deoxy-2-(2,2,2-trichloroethoxycarbonylamino)-α-D-glucopyranoside → C60H73Cl6N2O18P (206272-23-3)

Guidance literature:

Multi-step reaction with 6 steps

1: 70 percent / Sn(OTf)2 / diethyl ether / 2 h / -20 - 0 °C

2: BH₃*Me₂NH; BF₃*Et₂O / CH₂Cl₂ / 2 h / -40 - 0 °C

3: 325 mg / BF₃*Et₂O / CH₂Cl₂ / 1 h / 0 °C

4: 91 percent / molecular sieves 4A; trimethylsilyl triflate / 1,2-dichloro-ethane / 0.5 h / -20 °C

5: 98 percent / dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / 1,2-dichloro-ethane / 1 h / 20 °C

6: 85 percent / n-BuNH₂; HCOOH / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / tetrahydrofuran / 1 h / 20 °C

With dmap; tin(II) trifluoromethanesulfonate; formic acid; trimethylsilyl trifluoromethanesulfonate; dimethylamine borane; 4 A molecular sieve; boron trifluoride diethyl etherate; N-butylamine; dicyclohexyl-carbodiimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; dichloromethane; 1,2-dichloro-ethane; 1: Alkylation / 2: Ring cleavage / 3: dealkylation / 4: Condensation / 5: Acylation / 6: deprotection;

DOI:10.1016/S0040-4020(98)00133-1

Reference yield:

(3R)-3-hydroxydecanoic acid (19525-80-5) → C60H73Cl6N2O18P (206272-23-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 87 percent / triethylamine / ethyl acetate / 0 - 20 °C

2: 91 percent / hexamethyldisiloxane; TMSOTf; triethylsilane / tetrahydrofuran / 2.2 h / 0 °C

3: 71 percent / AcOH; zinc-copper couple / 2 h / 20 °C

4: 98 percent / dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / 1,2-dichloro-ethane / 1 h / 20 °C

5: 85 percent / n-BuNH₂; HCOOH / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / tetrahydrofuran / 1 h / 20 °C

With triethylsilane; dmap; formic acid; zinc copper; Hexamethyldisiloxane; trimethylsilyl trifluoromethanesulfonate; acetic acid; N-butylamine; triethylamine; dicyclohexyl-carbodiimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethyl acetate; 1,2-dichloro-ethane; 1: Esterification / 2: Alkylation / 3: Reduction / 4: Acylation / 5: deprotection;

DOI:10.1016/S0040-4020(98)00133-1

upstream raw materials:

C₆₄H₇₇Cl₆N₂O₂₀P

(3R)-3-hydroxydecanoic acid

N,N-diethyl-1,5-dihydro-3H-2,4,3-benzodioxaphosphepin-3-amine

phrnacyl (R)-3-hydroxydecanoate