trans-3-iodo-1-[4-(4-methylpiperazino)-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Base Information

Chemical Name:trans-3-iodo-1-[4-(4-methylpiperazino)-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS No.:461699-32-1
Molecular Formula:C₁₆H₂₄IN₇
Molecular Weight:441.318
Hs Code.:

Synonyms:trans-3-iodo-1-[4-(4-methylpiperazino)-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine

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Chemical Property of trans-3-iodo-1-[4-(4-methylpiperazino)-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine

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Technology Process of trans-3-iodo-1-[4-(4-methylpiperazino)-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine

There total 4 articles about trans-3-iodo-1-[4-(4-methylpiperazino)-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 109-01-3
1-methyl-piperazine

: 330792-72-8
4-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)cyclohexan-1-one

: 461699-32-1
trans-3-iodo-1-[4-(4-methylpiperazino)-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 40 ℃;
DOI:10.3987/COM-09-11857

Reference yield:

: 109-01-3
1-methyl-piperazine

AK: AK

: 330792-72-8
4-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)cyclohexan-1-one

: 461699-32-1
trans-3-iodo-1-[4-(4-methylpiperazino)-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; triethylamine; In methanol; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 2380-63-4
4-Aminopyrazolo<3,4-d>pyrimidin

: 461699-32-1
trans-3-iodo-1-[4-(4-methylpiperazino)-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-iodo-succinimide / N,N-dimethyl-formamide / 14 h / 80 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

3.1: 1,2-dichloro-ethane / 0.08 h / 0 °C / Inert atmosphere

3.2: 14 h / 20 °C / Inert atmosphere

With N-iodo-succinimide; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide;