Technology Process of (-)-3,4,5-trimethoxybenzyl leuconicine A
There total 13 articles about (-)-3,4,5-trimethoxybenzyl leuconicine A which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3,4,5-trimethoxybenzylamine;
With
trimethylaluminum;
In
dichloromethane; toluene;
at -15 - 20 ℃;
for 1.33333h;
leuconotis alkaloid 376;
In
dichloromethane; toluene;
Reflux;
DOI:10.1016/j.bmc.2013.12.022
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine / dichloromethane
2.1: triphenylphosphine; palladium diacetate / triethylamine
3.1: Raney Ni
4.1: trimethylaluminum / toluene; dichloromethane / 1.33 h / -15 - 20 °C
4.2: Reflux
With
trimethylaluminum; palladium diacetate; triethylamine; triphenylphosphine;
In
dichloromethane; triethylamine; toluene;
2.1: |Heck Reaction;
DOI:10.1016/j.bmc.2013.12.022
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: Lawessons reagent
2.1: triethyloxonium fluoroborate; sodium tetrahydroborate / methanol
3.1: N,O-dimethylhydroxylamine lithium amide
4.1: triethylamine / dichloromethane
5.1: triphenylphosphine; palladium diacetate / triethylamine
6.1: Raney Ni
7.1: trimethylaluminum / toluene; dichloromethane / 1.33 h / -15 - 20 °C
7.2: Reflux
With
Lawessons reagent; sodium tetrahydroborate; trimethylaluminum; triethyloxonium fluoroborate; palladium diacetate; triethylamine; triphenylphosphine; N,O-dimethylhydroxylamine lithium amide;
In
methanol; dichloromethane; triethylamine; toluene;
2.1: |Borch Reduction / 5.1: |Heck Reaction;
DOI:10.1016/j.bmc.2013.12.022
