(R)-3-((R)-2-(4-fluorophenylamino)-2-phenylacetoxy)-1-(2-(2-hydroxyphenyl)-2-oxoethyl)-1-azoniabicyclo[2.2.2]octane 2,2,2-trifluoroacetate

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Chemical Name:(R)-3-((R)-2-(4-fluorophenylamino)-2-phenylacetoxy)-1-(2-(2-hydroxyphenyl)-2-oxoethyl)-1-azoniabicyclo[2.2.2]octane 2,2,2-trifluoroacetate
CAS No.:1352633-81-8
Molecular Formula:C₂F₃O₂*C₂₉H₃₀FN₂O₄
Molecular Weight:602.583
Hs Code.:

Synonyms:(R)-3-((R)-2-(4-fluorophenylamino)-2-phenylacetoxy)-1-(2-(2-hydroxyphenyl)-2-oxoethyl)-1-azoniabicyclo[2.2.2]octane 2,2,2-trifluoroacetate

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Chemical Property of (R)-3-((R)-2-(4-fluorophenylamino)-2-phenylacetoxy)-1-(2-(2-hydroxyphenyl)-2-oxoethyl)-1-azoniabicyclo[2.2.2]octane 2,2,2-trifluoroacetate

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Technology Process of (R)-3-((R)-2-(4-fluorophenylamino)-2-phenylacetoxy)-1-(2-(2-hydroxyphenyl)-2-oxoethyl)-1-azoniabicyclo[2.2.2]octane 2,2,2-trifluoroacetate

There total 5 articles about (R)-3-((R)-2-(4-fluorophenylamino)-2-phenylacetoxy)-1-(2-(2-hydroxyphenyl)-2-oxoethyl)-1-azoniabicyclo[2.2.2]octane 2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.3%

: 1233329-28-6
(R)-(4-fluoro-phenylamino)-phenyl-acetic acid (R)-(1-azabicyclo[2.2.2]oct-3-yl)ester

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

: 76-05-1
trifluoroacetic acid

: 1352633-81-8
(R)-3-((R)-2-(4-fluorophenylamino)-2-phenylacetoxy)-1-(2-(2-hydroxyphenyl)-2-oxoethyl)-1-azoniabicyclo[2.2.2]octane 2,2,2-trifluoroacetate

Guidance literature:: (R)-(4-fluoro-phenylamino)-phenyl-acetic acid (R)-(1-azabicyclo[2.2.2]oct-3-yl)ester; 2-(2-bromoacetyl)hydroxybenzene; In ethyl acetate; at 20 ℃; for 17h;

trifluoroacetic acid;

Reference yield: 20.3%

: 1233329-28-6
(R)-(4-fluoro-phenylamino)-phenyl-acetic acid (R)-(1-azabicyclo[2.2.2]oct-3-yl)ester

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

: 1352633-81-8
(R)-3-((R)-2-(4-fluorophenylamino)-2-phenylacetoxy)-1-(2-(2-hydroxyphenyl)-2-oxoethyl)-1-azoniabicyclo[2.2.2]octane 2,2,2-trifluoroacetate

Guidance literature:: In ethyl acetate;

Reference yield:

: 25333-42-0
(R)-quinuclidin-3-ol

: 1352633-81-8
(R)-3-((R)-2-(4-fluorophenylamino)-2-phenylacetoxy)-1-(2-(2-hydroxyphenyl)-2-oxoethyl)-1-azoniabicyclo[2.2.2]octane 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 20 °C

2: acetone / Reflux

3: sodium carbonate / ethyl acetate; water

4: ethyl acetate / 17 h / 20 °C

With sodium carbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; water; ethyl acetate; acetone;