(4S,5R)-3-Benzyl-5-<(R)-(2-benzyloxy-1-hydroxy)ethyl>-4-cyclohexylmethyloxazolidin-2-one

Base Information

Chemical Name:(4S,5R)-3-Benzyl-5-<(R)-(2-benzyloxy-1-hydroxy)ethyl>-4-cyclohexylmethyloxazolidin-2-one
CAS No.:130914-07-7
Molecular Formula:C₂₆H₃₃NO₄
Molecular Weight:423.552
Hs Code.:

Synonyms:(4S,5R)-3-Benzyl-5-<(R)-(2-benzyloxy-1-hydroxy)ethyl>-4-cyclohexylmethyloxazolidin-2-one

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Chemical Property of (4S,5R)-3-Benzyl-5-<(R)-(2-benzyloxy-1-hydroxy)ethyl>-4-cyclohexylmethyloxazolidin-2-one

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Technology Process of (4S,5R)-3-Benzyl-5-<(R)-(2-benzyloxy-1-hydroxy)ethyl>-4-cyclohexylmethyloxazolidin-2-one

There total 21 articles about (4S,5R)-3-Benzyl-5-<(R)-(2-benzyloxy-1-hydroxy)ethyl>-4-cyclohexylmethyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 139056-96-5,139164-19-5
(4R,5R)-4-<(S)-(1-(N-Benzyl-N-methoxycarbonyl)amino-2-cyclohexyl)ethyl>-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane

: 130914-07-7
(4S,5R)-3-Benzyl-5-<(R)-(2-benzyloxy-1-hydroxy)ethyl>-4-cyclohexylmethyloxazolidin-2-one

Guidance literature:: With potassium hydroxide; acetic acid; Yield given. Multistep reaction; 1) 80 deg C, 5 h, 2) MeOH, r.t., 90 percent;
DOI:10.1246/cl.1990.1709

Reference yield:

: 130914-05-5
(4R,5R)-4-Benzyliminomethyl-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane

: 130914-07-7
(4S,5R)-3-Benzyl-5-<(R)-(2-benzyloxy-1-hydroxy)ethyl>-4-cyclohexylmethyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1) CeCl₃ / 1) THF, Et₂O, 0.5 h, -30 deg C, 2) THF, a) 2 h, -30 deg C, b) 12 h, r.t.

2: 97 percent / K₂CO₃ / tetrahydrofuran / 7 h / 0 °C

3: 80percent AcOH / 5 h / 80 °C

4: KOH / methanol / 3.5 h / Ambient temperature

With potassium hydroxide; cerium(III) chloride; potassium carbonate; acetic acid; In tetrahydrofuran; methanol;
DOI:10.1248/cpb.39.2550

Reference yield:

: 35166-78-0
cyclohexylmethyl magnesium bromide

: 130914-07-7
(4S,5R)-3-Benzyl-5-<(R)-(2-benzyloxy-1-hydroxy)ethyl>-4-cyclohexylmethyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1) CeCl₃ / 1) THF, Et₂O, 0.5 h, -30 deg C, 2) THF, a) 2 h, -30 deg C, b) 12 h, r.t.

2: 97 percent / K₂CO₃ / tetrahydrofuran / 7 h / 0 °C

3: 80percent AcOH / 5 h / 80 °C

4: KOH / methanol / 3.5 h / Ambient temperature

With potassium hydroxide; cerium(III) chloride; potassium carbonate; acetic acid; In tetrahydrofuran; methanol;
DOI:10.1248/cpb.39.2550