SDZ EAB 515

Base Information

• Chemical Name: SDZ EAB 515
• CAS No.: 118077-09-1
• Molecular Formula: C₁₆H₁₈NO₅P
• Molecular Weight: 335.296
• Mol file: 118077-09-1.mol

Synonyms:[1,1'-Biphenyl]-3-propanoicacid, a-amino-5-(phosphonomethyl)-,(S)-; EAB 515; SDZ-EAB 515

Chemical Property of SDZ EAB 515

Chemical Property:

• Vapor Pressure: 1.1E-15mmHg at 25°C
• Boiling Point: 609°Cat760mmHg
• Flash Point: 322.1°C
• PSA: 130.66000
• Density: 1.407g/cm³
• LogP: 2.68600

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of SDZ EAB 515

There total 14 articles about SDZ EAB 515 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-dimethylethyl (2S,5S)-5-<<5-<(diethoxyphosphoryl)methyl><1,1'-biphenyl>-3-yl>methyl>-2-(1,1-dimethylethyl)-3-methyl-4-oxoimidazolidine-1-carboxylate (142184-04-1) → (S)-α-amino-5-(phosphonomethyl)<1,1'-biphenyl>-3-propanoic acid (118077-09-1)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / Ambient temperature

2: 1.) 0.375M aq. H₂SO₄; 2.) Dowex 50 W / xylene / 1.) 70 deg C; 2.) reflux

With Dowex 50 W; sulfuric acid; In acetonitrile; xylene;

DOI:10.1002/hlca.19950780810

Reference yield:

(S)-2-Amino-3-[5-(diethoxy-phosphorylmethyl)-biphenyl-3-yl]-propionic acid → (S)-α-amino-5-(phosphonomethyl)<1,1'-biphenyl>-3-propanoic acid (118077-09-1)

Guidance literature:

With trimethylsilyl bromide; In dichloromethane; for 16h; Yield given; Ambient temperature;

DOI:10.1002/hlca.19920750320

Reference yield:

C28H45N2O4PSi2 → (S)-α-amino-5-(phosphonomethyl)<1,1'-biphenyl>-3-propanoic acid (118077-09-1)

Guidance literature:

With Dowex 50 W; sulfuric acid; In xylene; Yield given; 1.) 70 deg C; 2.) reflux;

DOI:10.1002/hlca.19950780810

upstream raw materials:

1-bromo-3,5-bis(bromomethyl)benzene

5-bromo-1,3-dihydroxymethylbenzene

1,1-dimethylethyl (2S,5S)-5-<<5-<(diethoxyphosphoryl)methyl><1,1'-biphenyl>-3-yl>methyl>-2-(1,1-dimethylethyl)-3-methyl-4-oxoimidazolidine-1-carboxylate

diethyl <<3-bromo-5-(bromomethyl)phenyl>methyl>phosphonate

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