1-sec-butyl-4-({[1-methyl-4-({4-[(E)-2-(3-quinolinyl)ethenyl]benzoyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-N-[2-(4-morpholinyl)ethyl]-1H-pyrrole-2-carboxamide

Base Information

Chemical Name:1-sec-butyl-4-({[1-methyl-4-({4-[(E)-2-(3-quinolinyl)ethenyl]benzoyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-N-[2-(4-morpholinyl)ethyl]-1H-pyrrole-2-carboxamide
CAS No.:1345417-80-2
Molecular Formula:C₃₉H₄₃N₇O₄
Molecular Weight:673.815
Hs Code.:

1-sec-butyl-4-({[1-methyl-4-({4-[(E)-2-(3-quinolinyl)ethenyl]benzoyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-N-[2-(4-morpholinyl)ethyl]-1H-pyrrole-2-carboxamide

Synonyms:1-sec-butyl-4-({[1-methyl-4-({4-[(E)-2-(3-quinolinyl)ethenyl]benzoyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-N-[2-(4-morpholinyl)ethyl]-1H-pyrrole-2-carboxamide

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Chemical Property of 1-sec-butyl-4-({[1-methyl-4-({4-[(E)-2-(3-quinolinyl)ethenyl]benzoyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-N-[2-(4-morpholinyl)ethyl]-1H-pyrrole-2-carboxamide

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Technology Process of 1-sec-butyl-4-({[1-methyl-4-({4-[(E)-2-(3-quinolinyl)ethenyl]benzoyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-N-[2-(4-morpholinyl)ethyl]-1H-pyrrole-2-carboxamide

There total 9 articles about 1-sec-butyl-4-({[1-methyl-4-({4-[(E)-2-(3-quinolinyl)ethenyl]benzoyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-N-[2-(4-morpholinyl)ethyl]-1H-pyrrole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1000277-46-2
4-[(E)-2-(3-quinolinyl)-ethenyl]benzoic acid

: C₂₁H₃₂N₆O₃

: 1345417-80-2
1-sec-butyl-4-({[1-methyl-4-({4-[(E)-2-(3-quinolinyl)ethenyl]benzoyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-N-[2-(4-morpholinyl)ethyl]-1H-pyrrole-2-carboxamide

Guidance literature:: With 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.08.035

Reference yield:

: 2038-03-1
4-(2-AMINOETHYL)MORPHOLINE

: 1345417-80-2
1-sec-butyl-4-({[1-methyl-4-({4-[(E)-2-(3-quinolinyl)ethenyl]benzoyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-N-[2-(4-morpholinyl)ethyl]-1H-pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 4-methyl-morpholine / dichloromethane

2: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 20 °C / Inert atmosphere

3: 4-methyl-morpholine / dichloromethane / 20 °C

4: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 0 °C / Inert atmosphere

5: 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide

With 4-methyl-morpholine; palladium 10% on activated carbon; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.08.035

Reference yield:

: 1345417-50-6
1-sec-butyl-4-nitro-1H-pyrrole-2-carboxylic acid

: 1345417-80-2
1-sec-butyl-4-({[1-methyl-4-({4-[(E)-2-(3-quinolinyl)ethenyl]benzoyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-N-[2-(4-morpholinyl)ethyl]-1H-pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride / 3 h / Reflux

2: 4-methyl-morpholine / dichloromethane

3: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 20 °C / Inert atmosphere

4: 4-methyl-morpholine / dichloromethane / 20 °C

5: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 0 °C / Inert atmosphere

6: 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide

With 4-methyl-morpholine; thionyl chloride; palladium 10% on activated carbon; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.08.035