ethyl 3,4-di-O-(6-(6-maleimidohexanamido)-3-thiahexyl)-2,6-di-O-methyl-α-D-galactopyranoside

Base Information

Chemical Name:ethyl 3,4-di-O-(6-(6-maleimidohexanamido)-3-thiahexyl)-2,6-di-O-methyl-α-D-galactopyranoside
CAS No.:680988-22-1
Molecular Formula:C₄₀H₆₄N₄O₁₂S₂
Molecular Weight:857.1
Hs Code.:

Synonyms:ethyl 3,4-di-O-(6-(6-maleimidohexanamido)-3-thiahexyl)-2,6-di-O-methyl-α-D-galactopyranoside

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Chemical Property of ethyl 3,4-di-O-(6-(6-maleimidohexanamido)-3-thiahexyl)-2,6-di-O-methyl-α-D-galactopyranoside

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Technology Process of ethyl 3,4-di-O-(6-(6-maleimidohexanamido)-3-thiahexyl)-2,6-di-O-methyl-α-D-galactopyranoside

There total 2 articles about ethyl 3,4-di-O-(6-(6-maleimidohexanamido)-3-thiahexyl)-2,6-di-O-methyl-α-D-galactopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: ethyl 3,4-di-O-(6-amino-3-thiahexyl)-2,6-di-O-methyl-α-D-galactopyranoside dihydrochloride

: 55750-63-5
6-maleimidohexanoic acid N-hydroxylsuccinimide ester

: 680988-22-1
ethyl 3,4-di-O-(6-(6-maleimidohexanamido)-3-thiahexyl)-2,6-di-O-methyl-α-D-galactopyranoside

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; water; at 0 - 5 ℃; for 1h;
DOI:10.1016/j.bmc.2004.04.008

Reference yield:

: 15486-24-5
ethyl α-D-galactopyranoside

: 680988-22-1
ethyl 3,4-di-O-(6-(6-maleimidohexanamido)-3-thiahexyl)-2,6-di-O-methyl-α-D-galactopyranoside

Guidance literature:: Multi-step reaction with 8 steps

1: 83 percent / pyridine / 2.5 h / 0 - 20 °C

2: 95 percent / p-TsOH / acetone / 3 h / 20 °C

3: 98 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 20 °C

4: 88 percent / NaH / dimethylformamide / 5 h / 0 - 20 °C

5: 99 percent / acetic acid / 2 h / 90 °C

6: 85 percent / NaH / dimethylformamide / 6 h / 0 - 20 °C

7: 90 percent / AIBN / methanol / 24 h / 20 °C / UV-irradiation

8: 42 percent / NaHCO₃ / H₂O; tetrahydrofuran / 1 h / 0 - 5 °C

With pyridine; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; sodium hydride; sodium hydrogencarbonate; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmc.2004.04.008