methyl 4-(1,9-dibenzyl-6,9-dihydro-6-oxo-1H-purin-8-yl)-2-hydroxy-4-oxobut-2-enoate

Base Information

Chemical Name:methyl 4-(1,9-dibenzyl-6,9-dihydro-6-oxo-1H-purin-8-yl)-2-hydroxy-4-oxobut-2-enoate
CAS No.:958867-89-5
Molecular Formula:C₂₄H₂₀N₄O₅
Molecular Weight:444.447
Hs Code.:

Synonyms:methyl 4-(1,9-dibenzyl-6,9-dihydro-6-oxo-1H-purin-8-yl)-2-hydroxy-4-oxobut-2-enoate

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Chemical Property of methyl 4-(1,9-dibenzyl-6,9-dihydro-6-oxo-1H-purin-8-yl)-2-hydroxy-4-oxobut-2-enoate

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Technology Process of methyl 4-(1,9-dibenzyl-6,9-dihydro-6-oxo-1H-purin-8-yl)-2-hydroxy-4-oxobut-2-enoate

There total 4 articles about methyl 4-(1,9-dibenzyl-6,9-dihydro-6-oxo-1H-purin-8-yl)-2-hydroxy-4-oxobut-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: methyl 4-(1,9-dibenzyl-6,9-dihydro-6-oxo-1H-purin-8-yl)-4-ethoxy-2-oxobut-3-enoate

: 958867-89-5
methyl 4-(1,9-dibenzyl-6,9-dihydro-6-oxo-1H-purin-8-yl)-2-hydroxy-4-oxobut-2-enoate

Guidance literature:: With iron(III) chloride; In 1,2-dichloro-ethane; for 3h; Heating;
DOI:10.1021/jo701336r

Reference yield: 91.0%

: Methyl 4-(1,9-benzyl-6,9-dihydro-6-oxo-1H-purin-8-yl)-4-ethoxy-2-oxo-but-3-enoate

: 958867-89-5
methyl 4-(1,9-dibenzyl-6,9-dihydro-6-oxo-1H-purin-8-yl)-2-hydroxy-4-oxobut-2-enoate

Guidance literature:: Methyl 4-(1,9-benzyl-6,9-dihydro-6-oxo-1H-purin-8-yl)-4-ethoxy-2-oxo-but-3-enoate; With iron(III) chloride; water; In dichloromethane; at 40 ℃; for 3h;

With hydrogenchloride; In water; for 0.0833333h;

Reference yield:

: 903594-16-1
1,9-dibenzyl-6,9-dihydro-6-oxo-8-bromopurine

: 958867-89-5
methyl 4-(1,9-dibenzyl-6,9-dihydro-6-oxo-1H-purin-8-yl)-2-hydroxy-4-oxobut-2-enoate

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / bis(triphenylphosphine)palladium dichloride / dimethylformamide / 22 h / 70 °C

2: 77 percent / pyridine / CHCl₃ / 48 h / 0 °C

3: 91 percent / iron(III) chloride hexahydrate / 1,2-dichloro-ethane / 3 h / Heating

With pyridine; iron(III) chloride; bis-triphenylphosphine-palladium(II) chloride; In chloroform; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 1: Stille cross-coupling;
DOI:10.1021/jo701336r