tert-Butyl-[(2R,4aR,6S,7R,8aS)-6-(4-iodo-3-methyl-butyl)-4a,6-dimethyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yloxy]-dimethyl-silane

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Chemical Name:tert-Butyl-[(2R,4aR,6S,7R,8aS)-6-(4-iodo-3-methyl-butyl)-4a,6-dimethyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yloxy]-dimethyl-silane
CAS No.:193697-83-5
Molecular Formula:C₂₆H₄₃IO₄Si
Molecular Weight:574.615
Hs Code.:

Synonyms:tert-Butyl-[(2R,4aR,6S,7R,8aS)-6-(4-iodo-3-methyl-butyl)-4a,6-dimethyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yloxy]-dimethyl-silane

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Chemical Property of tert-Butyl-[(2R,4aR,6S,7R,8aS)-6-(4-iodo-3-methyl-butyl)-4a,6-dimethyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yloxy]-dimethyl-silane

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Technology Process of tert-Butyl-[(2R,4aR,6S,7R,8aS)-6-(4-iodo-3-methyl-butyl)-4a,6-dimethyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yloxy]-dimethyl-silane

There total 3 articles about tert-Butyl-[(2R,4aR,6S,7R,8aS)-6-(4-iodo-3-methyl-butyl)-4a,6-dimethyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yloxy]-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 193697-82-4
4-[(2R,4aR,6S,7R,8aS)-7-(tert-Butyl-dimethyl-silanyloxy)-4a,6-dimethyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-2-methyl-butan-1-ol

: 193697-83-5
tert-Butyl-[(2R,4aR,6S,7R,8aS)-6-(4-iodo-3-methyl-butyl)-4a,6-dimethyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yloxy]-dimethyl-silane

Guidance literature:: With 1H-imidazole; iodine; triphenylphosphine; In benzene; for 0.333333h; Ambient temperature;
DOI:10.1021/ja971259t

Reference yield:

: (E)-4-[(2R,4aR,6S,7R,8aS)-7-(tert-Butyl-dimethyl-silanyloxy)-4a,6-dimethyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-2-methyl-but-2-enoic acid ethyl ester

: 193697-83-5
tert-Butyl-[(2R,4aR,6S,7R,8aS)-6-(4-iodo-3-methyl-butyl)-4a,6-dimethyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yloxy]-dimethyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / H₂ / Pd-C / ethyl acetate / 40 h

2: 95 percent / LiAlH₄ / diethyl ether / 0.67 h / Ambient temperature

3: 97 percent / I₂, PPh₃, imidazole / benzene / 0.33 h / Ambient temperature

With 1H-imidazole; lithium aluminium tetrahydride; hydrogen; iodine; triphenylphosphine; palladium on activated charcoal; In diethyl ether; ethyl acetate; benzene;
DOI:10.1021/ja971259t

Reference yield:

: 193697-81-3
4-[(2R,4aR,6S,7R,8aS)-7-(tert-Butyl-dimethyl-silanyloxy)-4a,6-dimethyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-2-methyl-butyric acid ethyl ester

: 193697-83-5
tert-Butyl-[(2R,4aR,6S,7R,8aS)-6-(4-iodo-3-methyl-butyl)-4a,6-dimethyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yloxy]-dimethyl-silane

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / LiAlH₄ / diethyl ether / 0.67 h / Ambient temperature

2: 97 percent / I₂, PPh₃, imidazole / benzene / 0.33 h / Ambient temperature

With 1H-imidazole; lithium aluminium tetrahydride; iodine; triphenylphosphine; In diethyl ether; benzene;
DOI:10.1021/ja971259t