N⁶-Benzoyl-9-<3'-bromo-3'-deoxy-2'-O-(monomethoxytrityl)-β-D-xylofuranosyl>adenine

Base Information

• Chemical Name: N⁶-Benzoyl-9-<3'-bromo-3'-deoxy-2'-O-(monomethoxytrityl)-β-D-xylofuranosyl>adenine
• CAS No.: 132849-58-2
• Molecular Formula: C₃₇H₃₂BrN₅O₅
• Molecular Weight: 706.596

Synonyms:N⁶-Benzoyl-9-<3'-bromo-3'-deoxy-2'-O-(monomethoxytrityl)-β-D-xylofuranosyl>adenine

Chemical Property of N⁶-Benzoyl-9-<3'-bromo-3'-deoxy-2'-O-(monomethoxytrityl)-β-D-xylofuranosyl>adenine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁶-Benzoyl-9-<3'-bromo-3'-deoxy-2'-O-(monomethoxytrityl)-β-D-xylofuranosyl>adenine

There total 6 articles about N⁶-Benzoyl-9-<3'-bromo-3'-deoxy-2'-O-(monomethoxytrityl)-β-D-xylofuranosyl>adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

N6-Benzoyl-9-<3'-bromo-3'-deoxy-2',5'-bis-O-(monomethoxytrityl)-β-D-xylofuranosyl>adenine (132849-57-1) → N6-Benzoyl-9-<3'-bromo-3'-deoxy-2'-O-(monomethoxytrityl)-β-D-xylofuranosyl>adenine (132849-58-2)

Guidance literature:

With acetic acid; at 4 ℃; for 18h;

DOI:10.1002/hlca.19910740104

Reference yield:

(2R,3S,4R,5R)-2-(6-amino-9H-purin-9-yl)-4-bromo-5(hydroxymethyl)tetrahydrofuran-3-ol (37731-73-0) → N6-Benzoyl-9-<3'-bromo-3'-deoxy-2'-O-(monomethoxytrityl)-β-D-xylofuranosyl>adenine (132849-58-2)

Guidance literature:

Multi-step reaction with 3 steps

2: 94 percent / pyridine / 3 h / Ambient temperature

3: 1.) pyridine, 2.) 80 percent AcOH / 1.) 50 deg C, 7 d, 2.) 4 deg C, 12 h

With pyridine; acetic acid;

DOI:10.1002/hlca.19910740104

Reference yield:

N6-Benzoyl-9-(3'-bromo-3'-deoxy-β-D-xylofuranosyl)adenine (132849-51-5) → N6-Benzoyl-9-<3'-bromo-3'-deoxy-2'-O-(monomethoxytrityl)-β-D-xylofuranosyl>adenine (132849-58-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / pyridine / 3 h / Ambient temperature

2: 1.) pyridine, 2.) 80 percent AcOH / 1.) 50 deg C, 7 d, 2.) 4 deg C, 12 h

With pyridine; acetic acid;

DOI:10.1002/hlca.19910740104

upstream raw materials:

N⁶-Benzoyl-9-<3'-bromo-3'-deoxy-2',5'-bis-O-(monomethoxytrityl)-β-D-xylofuranosyl>adenine

N⁶-Benzoyl-9-<3'-bromo-5'-O-<(tert-butyl)dimethylsilyl>-3'-deoxy-β-D-xylofuranosyl>adenine

mono-4-methoxytrityl chloride

(2R,3S,4R,5R)-2-(6-amino-9H-purin-9-yl)-4-bromo-5(hydroxymethyl)tetrahydrofuran-3-ol

Downstream raw materials:

N⁶-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenylyl-<2'-P-(2,5-dichlorophenyl)>->5'>-N⁶-benzoyl-3'-O-<(tert-butyl)dimethylsilyl>adenylyl-<2'-P-(2,5-dichlorophenyl)>->5'>-N⁶-benzoyl-9-<3'-bromo-3'-deoxy-2'-O-(mon...

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