Leu-Ala-Tyr-primaquine

Base Information

• Chemical Name: Leu-Ala-Tyr-primaquine
• CAS No.: 158306-85-5
• Molecular Formula: C₃₃H₄₆N₆O₅
• Molecular Weight: 606.765
• Mol file: 158306-85-5.mol

Synonyms:Leu-Ala-Tyr-primaquine

Chemical Property of Leu-Ala-Tyr-primaquine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Leu-Ala-Tyr-primaquine

There total 11 articles about Leu-Ala-Tyr-primaquine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Ala-Leu-Ala-Tyr-primaquine → Primaquine (90-34-6,57152-58-6) + Tyr-primaquine + Ala-Tyr-primaquine + Leu-Ala-Tyr-primaquine (158306-85-5)

Guidance literature:

With GLUTATHIONE; sodium phosphate buffer; lysosomal fraction from rat liver; In methanol; water; at 37 ℃; for 1h; Rate constant; Mechanism; further incubation times;

DOI:10.1002/jps.2600840227

Reference yield:

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) → Leu-Ala-Tyr-primaquine (158306-85-5)

Guidance literature:

Multi-step reaction with 10 steps

1: 1.) N,N'-dicyclohexylcarbodiimide, 2.) N-methylmorpholine / 1.) CH₂Cl₂, 0 deg C, 30 min, 2.) CH₂Cl₂, r.t., 20 h, pH = 7.5 - 9

2: 98 percent / 1M HCl/AcOH / 0.67 h / Ambient temperature

3: 1.) N,N'-dicyclohexylcarbodiimide, 2.) triethylamine / 1.) CH₂Cl₂, 0 deg C, 30 min, 2.) CH₂Cl₂, r.t., 20 h, pH = 7.5 - 9

4: 94 percent / H₂ / 10percent Pd/C / methanol / Ambient temperature

5: 1.) 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide, 2.) triethylamine / 1.) DMF, 0 deg C, 5 min; r.t., 2.) DMF, r.t., pH = 7.5 - 9

6: 98 percent / H₂ / 10percent Pd/C / methanol / Ambient temperature

7: 1.) 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide / 1.) DMF, 0 deg C, 5 min; r.t., 2.) DMF, r.t., 96 h

8: 98 percent / 1 h / Ambient temperature

9: pyridine; H₂O / 2 h / 50 °C

10: 1.) 100percent trifluoroacetic acid, 2.) 1M NaOH / 0.25 h / 50 °C / 2.) water, pH=14

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; hydrogen; benzotriazol-1-ol; acetic acid; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In pyridine; methanol; water;

DOI:10.1002/jps.2600840226

Reference yield:

N-((tert-butoxycarbonyl)-L-leucyl)-L-alanine benzyl ester (66415-01-8) → Leu-Ala-Tyr-primaquine (158306-85-5)

Guidance literature:

Multi-step reaction with 9 steps

1: 98 percent / 1M HCl/AcOH / 0.67 h / Ambient temperature

2: 1.) N,N'-dicyclohexylcarbodiimide, 2.) triethylamine / 1.) CH₂Cl₂, 0 deg C, 30 min, 2.) CH₂Cl₂, r.t., 20 h, pH = 7.5 - 9

3: 94 percent / H₂ / 10percent Pd/C / methanol / Ambient temperature

4: 1.) 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide, 2.) triethylamine / 1.) DMF, 0 deg C, 5 min; r.t., 2.) DMF, r.t., pH = 7.5 - 9

5: 98 percent / H₂ / 10percent Pd/C / methanol / Ambient temperature

6: 1.) 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide / 1.) DMF, 0 deg C, 5 min; r.t., 2.) DMF, r.t., 96 h

7: 98 percent / 1 h / Ambient temperature

8: pyridine; H₂O / 2 h / 50 °C

9: 1.) 100percent trifluoroacetic acid, 2.) 1M NaOH / 0.25 h / 50 °C / 2.) water, pH=14

With hydrogenchloride; sodium hydroxide; hydrogen; benzotriazol-1-ol; acetic acid; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In pyridine; methanol; water;

DOI:10.1002/jps.2600840226

upstream raw materials:

phenylthiocarbamyl-Ala-Leu-Ala-Tyr-primaquine

N-tert-butoxycarbonyl-L-leucine

N-((tert-butoxycarbonyl)-L-leucyl)-L-alanine benzyl ester

Boc-Ala-Leu-Ala

Downstream raw materials:

phenylthiocarbamyl-Leu-Ala-Tyr-primaquine